The sarcomeric proteins represent the structural building blocks of heart muscle, which are
essential for contraction and relaxation. During recent years, it has become evident that …

The molecular mechanism by which Ca 2+ binding and phosphorylation regulate muscle
contraction through Troponin is not yet fully understood. Revealing the differences between …

The sarcomere as the smallest contractile unit is prone to alterations in its functional,
structural and associated proteins. Sarcomeric dysfunction leads to heart failure or …

All muscle contraction occurs due to the cyclical interaction between sarcomeric thin and
thick filament proteins within the myocyte. The thin filament consists of the proteins actin …

Cardiovascular diseases (CVDs) present a major social problem worldwide due to their high
incidence and mortality rate. Many pathophysiological mechanisms are involved in CVDs …

Cardiomyopathies represent a heterogeneous group of diseases that negatively affect heart
function. Primary cardiomyopathies specifically target the myocardium, and may arise from …

Restrictive cardiomyopathy (RCM), a potentially devastating heart muscle disorder, is
characterized by diastolic dysfunction due to abnormal muscle relaxation and myocardial …

Reversible Ca2+ binding to troponin is the primary on-off switch of the contractile apparatus
of striated muscles, including the heart. Dominant missense mutations in human cardiac …

Abstract The Frank–Starling Law dictates that the heart is able to match ejection to the
dynamic changes occurring during cardiac filling, hence efficiently regulating isovolumetric …

In cardiac muscle the action of adrenaline on β1 receptors of heart muscle cells is essential
to adjust cardiac output to the body's needs. Adrenergic activation leads to enhanced …