Strategies to address low drug solubility in discovery and development

HD Williams, NL Trevaskis, SA Charman… - Pharmacological …, 2013 - Elsevier
Drugs with low water solubility are predisposed to low and variable oral bioavailability and,
therefore, to variability in clinical response. Despite significant efforts to “design in” …

Micellization of block copolymers

G Riess - Progress in polymer science, 2003 - Elsevier
This article deals with recent progress including the author's work in the field of block
copolymer self-assembly in solution and on solid surfaces. The synthesis methods for …

Iron oxide nanoparticles for sustained delivery of anticancer agents

TK Jain, MA Morales, SK Sahoo… - Molecular …, 2005 - ACS Publications
We have developed a novel water-dispersible oleic acid (OA)-Pluronic-coated iron oxide
magnetic nanoparticle formulation that can be loaded easily with high doses of water …

Encapsulation of hydrophobic drugs in Pluronic F127 micelles: effects of drug hydrophobicity, solution temperature, and pH

R Basak, R Bandyopadhyay - Langmuir, 2013 - ACS Publications
Three drugs, ibuprofen, aspirin, and erythromycin, are encapsulated in spherical Pluronic
F127 micelles. The shapes and the size distributions of the micelles in dilute, aqueous …

Poly (ethylene oxide)–poly (propylene oxide) block copolymer micelles as drug delivery agents: improved hydrosolubility, stability and bioavailability of drugs

DA Chiappetta, A Sosnik - European Journal of Pharmaceutics and …, 2007 - Elsevier
The low solubility in biological fluids displayed by about 50% of the drugs still remains the
main limitation in oral, parenteral, and transdermal administration. Among the existing …

Amphiphilic block copolymers in drug delivery: Advances in formulation structure and performance

AM Bodratti, P Alexandridis - Expert opinion on drug delivery, 2018 - Taylor & Francis
Introduction: Nanostructured delivery vehicles can address key challenges facing drug
delivery, including the lipophilic nature of therapeutic compounds and their effective …

Dye-doped silica nanoparticles as luminescent organized systems for nanomedicine

M Montalti, L Prodi, E Rampazzo… - Chemical Society …, 2014 - pubs.rsc.org
The ability to find synergic solutions is the core of scientific research and scientific
advancement. This is particularly true for medicine, where multimodal imaging and …

Thermoreversible Pluronic® F127-based hydrogel containing liposomes for the controlled delivery of paclitaxel: in vitro drug release, cell cytotoxicity, and uptake …

S Nie, WLW Hsiao, W Pan, Z Yang - International journal of …, 2011 - Taylor & Francis
Purpose To develop an in situ gel system comprising liposome-containing paclitaxel (PTX)
dispersed within the thermoreversible gel (Pluronic® F127 gel) for controlled release and …

Pluronic additives: a solution to sticky problems in digital microfluidics

VN Luk, GCH Mo, AR Wheeler - Langmuir, 2008 - ACS Publications
Digital microfluidics (DMF) is a promising technique for carrying out miniaturized, automated
biochemical assays in which discrete droplets of reagents are actuated on the surface of an …

High‐yield synthesis of periodic mesoporous silica rods and their replication to mesoporous carbon rods

C Yu, J Fan, B Tian, D Zhao, GD Stucky - Advanced Materials, 2002 - Wiley Online Library
Ordered mesoporous carbon rods have been obtained in high yield using silica rods as
templates. The inorganic salts that are used for the synthesis of the silica templates control …