[HTML][HTML] mRNA-based therapeutics: powerful and versatile tools to combat diseases
S Qin, X Tang, Y Chen, K Chen, N Fan… - Signal transduction and …, 2022 - nature.com
The therapeutic use of messenger RNA (mRNA) has fueled great hope to combat a wide
range of incurable diseases. Recent rapid advances in biotechnology and molecular …
range of incurable diseases. Recent rapid advances in biotechnology and molecular …
[HTML][HTML] Animal models for COVID-19: hamsters, mouse, ferret, mink, tree shrew, and non-human primates
S Shou, M Liu, Y Yang, N Kang, Y Song… - Frontiers in …, 2021 - frontiersin.org
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a novel coronavirus
causing acute respiratory tract infection in humans. The virus has the characteristics of rapid …
causing acute respiratory tract infection in humans. The virus has the characteristics of rapid …
[HTML][HTML] A variant-proof SARS-CoV-2 vaccine targeting HR1 domain in S2 subunit of spike protein
W Pang, Y Lu, YB Zhao, F Shen, CF Fan, Q Wang… - Cell Research, 2022 - nature.com
The emerging SARS-CoV-2 variants, commonly with many mutations in S1 subunit of spike
(S) protein are weakening the efficacy of the current vaccines and antibody therapeutics …
(S) protein are weakening the efficacy of the current vaccines and antibody therapeutics …
[HTML][HTML] A novel STING agonist-adjuvanted pan-sarbecovirus vaccine elicits potent and durable neutralizing antibody and T cell responses in mice, rabbits and NHPs
Z Liu, J Zhou, W Xu, W Deng, Y Wang, M Wang… - Cell research, 2022 - nature.com
The emergence of SARS-CoV-2 variants and potentially other highly pathogenic
sarbecoviruses in the future highlights the need for pan-sarbecovirus vaccines. Here, we …
sarbecoviruses in the future highlights the need for pan-sarbecovirus vaccines. Here, we …
[HTML][HTML] Characterization of SARS-CoV-2-specific humoral immunity and its potential applications and therapeutic prospects
J Zheng, Y Deng, Z Zhao, B Mao, M Lu, Y Lin… - Cellular & molecular …, 2022 - nature.com
Abstract Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2), is an ongoing pandemic that poses a great threat to …
syndrome coronavirus 2 (SARS-CoV-2), is an ongoing pandemic that poses a great threat to …
[HTML][HTML] COVID-19 vaccines: current understanding on immunogenicity, safety, and further considerations
Q He, Q Mao, J Zhang, L Bian, F Gao, J Wang… - Frontiers in …, 2021 - frontiersin.org
The world has entered the second wave of the COVID-19 pandemic, and its intensity is
significantly higher than that of the first wave of early 2020. Many countries or regions have …
significantly higher than that of the first wave of early 2020. Many countries or regions have …
[HTML][HTML] The role of B cells in COVID-19 infection and vaccination
S Chen, F Guan, F Candotti, K Benlagha… - Frontiers in …, 2022 - frontiersin.org
B cells secrete antibodies and mediate the humoral immune response, making them
extremely important in protective immunity against SARS-CoV-2, which caused the …
extremely important in protective immunity against SARS-CoV-2, which caused the …
[HTML][HTML] Antibodies and vaccines target RBD of SARS-CoV-2
L Min, Q Sun - Frontiers in Molecular Biosciences, 2021 - frontiersin.org
The novel human coronavirus, severe acute respiratory syndrome coronavirus-2 (SARS-
CoV-2), which gives rise to the coronavirus disease 2019 (COVID-19), has caused a serious …
CoV-2), which gives rise to the coronavirus disease 2019 (COVID-19), has caused a serious …
Impact of the SARS‐CoV‐2 virus on male reproductive health
DE Nassau, JC Best, E Kresch, DC Gonzalez… - BJU …, 2022 - Wiley Online Library
The coronavirus 2019 (COVID‐19) pandemic caused by the novel severe acute respiratory
syndrome coronavirus 2 (SARS‐CoV‐2) has led to more than 160 million infections and 3.5 …
syndrome coronavirus 2 (SARS‐CoV‐2) has led to more than 160 million infections and 3.5 …
SARS-CoV-2 Omicron subvariants exhibit distinct fusogenicity, but similar sensitivity, to pan-CoV fusion inhibitors
S Xia, L Wang, F Jiao, X Yu, W Xu… - Emerging Microbes & …, 2023 - Taylor & Francis
Continuous emergence of the Omicron variant, along with its subvariants, has caused an
increasing number of infections, reinfections, and vaccine-breakthrough infections, seriously …
increasing number of infections, reinfections, and vaccine-breakthrough infections, seriously …