Purpose Survival and progression of mature B-cell malignancies depend on signals from the
B-cell antigen receptor, and Bruton tyrosine kinase (BTK) is a critical signaling kinase in this …

Human neutrophil gelatinase-associated lipocalin (NGAL) is a glycoprotein present in a
wide variety of tissues and cell types. NGAL exists as a 25 kDa monomer, a 46 kDa …

Small-molecule drugs that target the B-cell antigen receptor (BCR) signalosome show
clinical efficacy in the treatment of B-cell non-Hodgkin lymphoma. These agents, including …

We report here that in chronic lymphocytic leukemia (CLL), the propensity to generate clonal
B cells has been acquired already at the hematopoietic stem cell (HSC) stage. HSCs …

The Bcl-2 protein, best known for its ability to inhibit apoptosis, interacts with the inositol 1, 4,
5-trisphosphate receptor (IP3R) Ca2+ channel to regulate IP3-mediated Ca2+ release from …

Chronic lymphocytic leukemia is marked by profound defects in T-cell function. Programmed
death-1 is a receptor involved in tumor-mediated immunosuppression through binding of the …

A circuit level understanding of immune cells and hematological cancers has been severely
impeded by a lack of techniques that enable intracellular perturbation without significantly …

Individual cytokines and groups of cytokines that might represent networks in chronic
lymphocytic leukemia (CLL) were analyzed and their prognostic values determined. Serum …

While research on T cell exhaustion in context of cancer particularly focuses on CD8+
cytotoxic T cells, the role of inhibitory receptors on CD4+ T-helper cells have remained …

Survival of chronic lymphocytic leukemia (CLL) cells strictly depends on the support of an
appropriate tumor microenvironment. Here, we demonstrate that LYN kinase is essential for …