Achieving complete understanding of any living thing inevitably requires thorough analysis
of both its anatomic and dynamic properties. Live-cell imaging experiments carried out to …

Migration is a polarized cellular process that opposes a protrusive front edge to a retracting
trailing edge. From the front to the rear, actin-mediated forces sequentially promote cell …

In eukaryotic cells, organelles and the cytoskeleton undergo highly dynamic yet organized
interactions capable of orchestrating complex cellular functions. Visualizing these …

Mechanical signals from the tumor microenvironment modulate cell mechanics and
influence cell metabolism to promote cancer aggressiveness. Cells withstand external forces …

Optimal four-dimensional imaging requires high spatial resolution in all dimensions, high
speed and minimal photobleaching and damage. We developed a dual-view, plane …

Microtubules define the architecture and internal organization of cells by positioning
organelles and activities, as well as by supporting cell shape and mechanics. One of the …

Variability characterizes the complexity of biological systems and is essential for their
function. Microtubules (MTs) play a role in structural integrity, cell motility, material transport …

Here we introduce plusTipTracker, a Matlab-based open source software package that
combines automated tracking, data analysis, and visualization tools for movies of …

In developmental biology, knowledge of cell structure and their (morpho) dynamic behavior,
leads to a comprehensive understanding of their conducts and the mechanisms in which …

Mechanical cues influence pluripotent stem cell differentiation, but the underlying
mechanisms are not well understood. Mouse embryonic stem cells (mESCs) exhibit unusual …