The great immune escape: understanding the divergent immune response in breast cancer subtypes

SS Onkar, NM Carleton, PC Lucas, TC Bruno, AV Lee… - Cancer discovery, 2023 - AACR
Breast cancer, the most common type of cancer affecting women, encompasses a collection
of histologic (mainly ductal and lobular) and molecular subtypes exhibiting diverse clinical …

Is cancer biology different in older patients?

Y Van Herck, A Feyaerts, S Alibhai… - The Lancet Healthy …, 2021 - thelancet.com
Roughly 50% of cancer cases occur in people aged 65 years or older. Older people are
often diagnosed at a later stage and might receive less (intensive) treatment, which might …

Immune infiltration in renal cell carcinoma

S Zhang, E Zhang, J Long, Z Hu, J Peng, L Liu… - Cancer …, 2019 - Wiley Online Library
Immune infiltration of tumors is closely associated with clinical outcome in renal cell
carcinoma (RCC). Tumor‐infiltrating immune cells (TIIC s) regulate cancer progression and …

Invasive lobular carcinoma of the breast: the increasing importance of this special subtype

AE McCart Reed, L Kalinowski, PT Simpson… - Breast Cancer …, 2021 - Springer
Invasive lobular carcinoma (ILC) is the most common of the breast cancer special types,
accounting for up to 15% of all breast cancer cases. ILCs are noted for their lack of E …

[HTML][HTML] Current and future diagnostic and treatment strategies for patients with invasive lobular breast cancer

K Van Baelen, T Geukens, M Maetens… - Annals of …, 2022 - Elsevier
Background Invasive lobular breast cancer (ILC) is the second most common type of breast
cancer after invasive breast cancer of no special type (NST), representing up to 15% of all …

The tale of TILs in breast cancer: a report from the international immuno-oncology biomarker working group

K El Bairi, HR Haynes, E Blackley, S Fineberg… - NPJ breast …, 2021 - nature.com
The advent of immune-checkpoint inhibitors (ICI) in modern oncology has significantly
improved survival in several cancer settings. A subgroup of women with breast cancer (BC) …

Immune landscape in invasive ductal and lobular breast cancer reveals a divergent macrophage-driven microenvironment

S Onkar, J Cui, J Zou, C Cardello, AR Cillo, MR Uddin… - Nature Cancer, 2023 - nature.com
T cell-centric immunotherapies have shown modest clinical benefit thus far for estrogen
receptor-positive (ER+) breast cancer. Despite accounting for 70% of all breast cancers …

Breast cancer: a molecularly heterogenous disease needing subtype-specific treatments

U Testa, G Castelli, E Pelosi - Medical Sciences, 2020 - mdpi.com
Breast cancer is the most commonly occurring cancer in women. There were over two-
million new cases in world in 2018. It is the second leading cause of death from cancer in …

Invasive lobular carcinoma: an understudied emergent subtype of breast cancer

JA Mouabbi, A Hassan, B Lim, GN Hortobagyi… - Breast cancer research …, 2022 - Springer
Invasive lobular carcinoma (ILC) is the second most common histologic subtype of breast
cancer after invasive ductal carcinoma (IDC), accounting for 10–15% of all breast cancer …

CIBERSORT analysis of TCGA and METABRIC identifies subgroups with better outcomes in triple negative breast cancer

KE Craven, Y Gökmen-Polar, SS Badve - Scientific Reports, 2021 - nature.com
Studies have shown that the presence of tumor infiltrating lymphocytes (TILs) in Triple
Negative Breast Cancer (TNBC) is associated with better prognosis. However, the molecular …