Selenium and selenoproteins in health

F Zhang, X Li, Y Wei - Biomolecules, 2023 - mdpi.com
Selenium is a trace mineral that is essential for health. After being obtained from food and
taken up by the liver, selenium performs various physiological functions in the body in the …

Supplementation of micronutrient selenium in metabolic diseases: its role as an antioxidant

N Wang, HY Tan, S Li, Y Xu, W Guo… - Oxidative medicine and …, 2017 - Wiley Online Library
Selenium is an essential mineral naturally found in soil, water, and some of the food. As an
antioxidant, it is one of the necessary trace elements in human body and has been …

Selenium and endocrine systems

GJ Beckett, JR Arthur - Journal of endocrinology, 2005 - joe.bioscientifica.com
The trace element selenium (Se) is capable of exerting multiple actions on endocrine
systems by modifying the expression of at least 30 selenoproteins, many of which have …

Selenium and diabetes—evidence from animal studies

J Zhou, K Huang, XG Lei - Free Radical Biology and Medicine, 2013 - Elsevier
Whereas selenium was found to act as an insulin mimic and to be antidiabetic in earlier
studies, recent animal experiments and human trials have shown an unexpected risk of …

Fish, mercury, selenium and cardiovascular risk: current evidence and unanswered questions

D Mozaffarian - International journal of environmental research and …, 2009 - mdpi.com
Controversy has arisen among the public and in the media regarding the health effects of
fish intake in adults. Substantial evidence indicates that fish consumption reduces coronary …

Selenium supranutrition: are the potential benefits of chemoprevention outweighed by the promotion of diabetes and insulin resistance?

CRB Rocourt, WH Cheng - Nutrients, 2013 - mdpi.com
Selenium was considered a toxin until 1957, when this mineral was shown to be essential in
the prevention of necrotic liver damage in rats. The hypothesis of selenium chemoprevention …

Protective role of antioxidants in diabetes-induced cardiac dysfunction

G Vassort, B Turan - Cardiovascular toxicology, 2010 - Springer
Cardiac dysfunction occurs during type 1 and type 2 diabetes and results from multiple
parameters including glucotoxicity, lipotoxicity, fibrosis and mitochondrial uncoupling …

Role of antioxidants in redox regulation of diabetic cardiovascular complications

B Turan - Current pharmaceutical biotechnology, 2010 - ingentaconnect.com
Cardiovascular dysfunction is leading cause for the mortality of diabetic individuals, in part
due to a specific cardiomyopathy, and due to altered endothelial dependent/independent …

Selenium prevents diabetes-induced alterations in [Zn2+]i and metallothionein level of rat heart via restoration of cell redox cycle

M Ayaz, B Turan - American Journal of Physiology-Heart …, 2006 - journals.physiology.org
Intracellular free zinc concentration ([Zn2+] i) is very important for cell functions, and its
excessive accumulation is cytotoxic.[Zn2+] i can increase rapidly in cardiomyocytes because …

Effects of selenium on altered mechanical and electrical cardiac activities of diabetic rat

M Ayaz, S Ozdemir, M Ugur, G Vassort… - Archives of Biochemistry …, 2004 - Elsevier
Since selenium compounds can restore some metabolic parameters and structural
alterations of diabetic rat heart, we were tempted to investigate whether these beneficial …