Clinical relevance of dissolution testing in quality by design
PA Dickinson, WW Lee, PW Stott, AI Townsend… - The AAPS journal, 2008 - Springer
Quality by design (QbD) has recently been introduced in pharmaceutical product
development in a regulatory context and the process of implementing such concepts in the …
development in a regulatory context and the process of implementing such concepts in the …
Predicting pharmacokinetics of drugs using physiologically based modeling—application to food effects
N Parrott, V Lukacova, G Fraczkiewicz, MB Bolger - The AAPS journal, 2009 - Springer
Our knowledge of the major mechanisms underlying the effect of food on drug absorption
allows reliable qualitative prediction based on biopharmaceutical properties, which can be …
allows reliable qualitative prediction based on biopharmaceutical properties, which can be …
Towards prediction of in vivo intestinal absorption using a 96-well Caco-2 assay
S Skolnik, X Lin, J Wang, XH Chen, T He… - Journal of pharmaceutical …, 2010 - Elsevier
We systematically validated a robust 96-well Caco-2 assay via an extended set of 93
marketed drugs with diverse transport mechanisms and quantified by LC/MS/MS, to …
marketed drugs with diverse transport mechanisms and quantified by LC/MS/MS, to …
Applications of physiologically based absorption models in drug discovery and development
This article describes the use of physiologically based models of intestinal drug absorption
to guide the research and development of new drugs. Applications range from lead …
to guide the research and development of new drugs. Applications range from lead …
Prediction of Modified Release Pharmacokinetics and Pharmacodynamics from In Vitro, Immediate Release, and Intravenous Data
V Lukacova, WS Woltosz, MB Bolger - The AAPS journal, 2009 - Springer
The aim of this study was to demonstrate the value of mechanistic simulations in gaining
insight into the behaviors of modified release (MR) formulations in vivo and to use the …
insight into the behaviors of modified release (MR) formulations in vivo and to use the …
The role of paracellular transport in the intestinal absorption and biopharmaceutical characterization of minoxidil
M Markovic, M Zur, S Garsiani, D Porat, S Cvijić… - Pharmaceutics, 2022 - mdpi.com
The purpose of this study was to evaluate mechanisms behind the intestinal permeability of
minoxidil, with special emphasis on paracellular transport, and elucidate the suitability of …
minoxidil, with special emphasis on paracellular transport, and elucidate the suitability of …
Physiologically based pharmacokinetic modeling in lead optimization. 1. Evaluation and adaptation of gastroplus to predict bioavailability of medchem series
When medicinal chemists need to improve bioavailability (% F) within a chemical series
during lead optimization, they synthesize new series members with systematically modified …
during lead optimization, they synthesize new series members with systematically modified …
Physiologically based pharmacokinetic modeling in lead optimization. 2. Rational bioavailability design by global sensitivity analysis to identify properties affecting …
When medicinal chemists need to improve oral bioavailability (% F) during lead
optimization, they systematically modify compound properties mainly based on their own …
optimization, they systematically modify compound properties mainly based on their own …
Computational Modeling of Drug Oral Bioavailability
LWR Fong, B Huang, R Chaudhari… - Oral Bioavailability and …, 2023 - Wiley Online Library
The oral bioavailability of a drug is a critical factor in determining its therapeutic efficacy.
Computational modeling approaches have emerged as valuable tools for predicting drug …
Computational modeling approaches have emerged as valuable tools for predicting drug …
Modeling of absorption
WS Woltosz, MB Bolger, V Lukacova - Computational Toxicology: Volume …, 2012 - Springer
Absorption takes place when a compound enters an organism, which occurs as soon as the
molecules enter the first cellular bilayer (s) in the tissue (s) to which is it exposed. At that …
molecules enter the first cellular bilayer (s) in the tissue (s) to which is it exposed. At that …