HIV reverse transcriptase (RT) is an enzyme that plays a major role in the replication cycle of
HIV and has been a key target of anti-HIV drug development efforts. Because of the high …

Proline is a non‐toxic and inexpensive natural amino acid that is readily available in both
enantiomeric forms and was one of the very first compounds to be studied as an …

The introduction of potent combination therapies in the mid-90s had a tremendous effect on
AIDS mortality. However, drug resistance has been a major factor contributing to …

More than 40 years into the pandemic, HIV remains a global burden and as of now, there is
no cure in sight. Fortunately, highly active antiretroviral therapy (HAART) has been …

During the retrotranscription process, characteristic of all retroviruses, the viral ssRNA
genome is converted into integration‐competent dsDNA. This process is accomplished by …

One to two million people worldwide are infected with the human immunodeficiency virus
type 2 (HIV-2), with highest prevalences in West African countries, but also present in …

Background: L-proline is a natural amino acid having secondary amine functionality and
acts as a bifunctional catalyst (organo-catalyst). The amino-functional group acts as Lewis …

Retroviruses consume cellular deoxynucleoside triphosphates (dNTPs) to convert their RNA
genomes into proviral DNA through reverse transcription. While all retroviruses replicate in …

The enzyme reverse transcriptase (RT) plays a central role in the life cycle of human
immunodeficiency virus (HIV), and RT has been an important drug target. Elucidations of the …

Synthesis of integration-competent, double-stranded DNA from the (+)-RNA strand genome
of retroviruses and long terminal repeat-containing retrotransposons reflects a multistep …