P-glycoprotein (P-gp) is a major factor in the multidrug resistance phenotype in cancer cells.
P-gp is a protein that regulates the ATP-dependent efflux of a wide range of anticancer …

Natural products are small molecules naturally produced by multiple sources such as plants,
animals, fungi, bacteria and archaea. They exert both beneficial and detrimental effects by …

Glycogen metabolism is an important biological process for organisms. In Caenorhabditis
elegans, effect of 6-PPD quinone (6-PPDQ) on glycogen accumulation and underlying …

Recently, the transgenerational toxicity of nanoplastics has received increasing attention.
Caenorhabditis elegans is a useful model to assess the transgenerational toxicity of different …

The neurotransmitter serotonin plays a central role in animal behavior and physiology, and
many of its functions are regulated via evolutionarily conserved biosynthesis and …

Uridine diphosphate sugar-utilizing glycosyltransferases (UGTs) are an enzyme superfamily
that catalyzes glycosyl residues transfer from activated nucleotide sugars to acceptor …

The fungus Rhizopus microsporus harbors a bacterial endosymbiont (Mycetohabitans
rhizoxinica) for the production of the antimitotic toxin rhizoxin. Although rhizoxin is the …

The genetic variability of toxicant responses among indisviduals in humans and mammalian
models requires practically untenable sample sizes to create comprehensive chemical …

The complex, variable mixtures present in fine particulate matter (PM2. 5) have been well
established, and associations between chemical constituents and human health are …

Some epigenetic information can be transmitted between generations without changes in
the underlying DNA sequence. Changes in epigenetic regulators, termed epimutations, can …