Pre-eclampsia: pathophysiology and clinical implications

GJ Burton, CW Redman, JM Roberts, A Moffett - Bmj, 2019 - bmj.com
Pre-eclampsia is a common disorder that particularly affects first pregnancies. The clinical
presentation is highly variable but hypertension and proteinuria are usually seen. These …

Does race or ethnicity play a role in the origin, pathophysiology, and outcomes of preeclampsia? An expert review of the literature

JD Johnson, JM Louis - American journal of obstetrics and gynecology, 2022 - Elsevier
The burden of preeclampsia, a substantial contributor to perinatal morbidity and mortality, is
not born equally across the population. Although the prevalence of preeclampsia has been …

Prevalence of preeclampsia and eclampsia in adolescent pregnancy: A systematic review and meta-analysis of 291,247 adolescents worldwide since 1969

TCC Macedo, E Montagna, CM Trevisan, V Zaia… - European Journal of …, 2020 - Elsevier
Objective Hypertensive disorders are among the main causes of maternal and perinatal
morbidity and mortality, and the findings regarding the occurrence of preeclampsia (PE) and …

Prospective evaluation of cardiovascular risk 10 years after a hypertensive disorder of pregnancy

LD Levine, B Ky, JA Chirinos, J Koshinksi… - Journal of the American …, 2022 - jacc.org
Background Hypertensive disorders of pregnancy (HDP) are associated with increased risk
of cardiovascular disease (CVD) 20-30 years later; however, cardiovascular (CV) risk in the …

Review of the immune mechanisms of preeclampsia and the potential of immune modulating therapy

YC Ai-ris, LA Smith, SA Karumanchi - Human immunology, 2021 - Elsevier
Successful pregnancy relies on maternal immunologic tolerance mechanisms limit
maladaptive immune responses against the semi-allogeneic fetus and placenta and support …

[HTML][HTML] Two distinct molecular faces of preeclampsia revealed by single-cell transcriptomics

I Admati, N Skarbianskis, H Hochgerner, O Ophir… - Med, 2023 - cell.com
Introduction Preeclampsia is a multisystemic, pregnancy-specific disorder united by new-
onset hypertension but with considerable variation in clinical manifestation, onset, and …

Trace minerals, heavy metals, and preeclampsia: findings from the Boston Birth Cohort

T Liu, M Zhang, E Guallar, G Wang… - Journal of the …, 2019 - Am Heart Assoc
Background Preeclampsia is a leading contributor to maternal and perinatal morbidity and
mortality. In mice experiments, manganese (Mn) and selenium (Se) are protective whereas …

Hypertensive disorders of pregnancy and risk of stroke in US Black women

S Sheehy, HJ Aparicio, N Xu, KA Bertrand… - NEJM …, 2023 - evidence.nejm.org
Background Black women have a disproportionately higher burden of both preeclamptic
pregnancy and stroke compared with White women, but virtually all existing evidence on this …

Variations in cardiovascular structure, function, and geometry in midlife associated with a history of hypertensive pregnancy

H Boardman, P Lamata, M Lazdam, A Verburg… - …, 2020 - Am Heart Assoc
Hypertensive pregnancy is associated with increased maternal cardiovascular risk in later
life. A range of cardiovascular adaptations after pregnancy have been reported to partly …

Statins in pre‐eclampsia or fetal growth restriction: A systematic review and meta‐analysis on maternal blood pressure and fetal growth across species

L Meijerink, KE Wever, F Terstappen… - … Journal of Obstetrics …, 2023 - Wiley Online Library
Background Several human randomised controlled trials (RCTs) are investigating the effects
of statins on pre‐eclampsia (PE) and fetal growth restriction (FGR). This cross‐species meta …