Human genetic adaptation to high altitude

LG Moore - High altitude medicine & biology, 2001 - liebertpub.com
Some 140 million persons live permanently at high altitudes (> 2500 m) in North, Central
and South America, East Africa, and Asia. Reviewed here are recent studies which address …

Population genetics, history, and health patterns in Native Americans

CJ Mulligan, K Hunley, S Cole… - Annu. Rev. Genomics …, 2004 - annualreviews.org
▪ Abstract Over the past two decades, detailed studies of mitochondrial DNA and the Y
chromosome have increased our understanding of the history and population genetics of …

Evolutionary genomic dynamics of Peruvians before, during, and after the Inca Empire

DN Harris, W Song, AC Shetty… - Proceedings of the …, 2018 - National Acad Sciences
Native Americans from the Amazon, Andes, and coastal geographic regions of South
America have a rich cultural heritage but are genetically understudied, therefore leading to …

Rapid coastal spread of First Americans: Novel insights from South America's Southern Cone mitochondrial genomes

M Bodner, UA Perego, G Huber, L Fendt… - Genome …, 2012 - genome.cshlp.org
It is now widely agreed that the Native American founders originated from a Beringian
source population∼ 15–18 thousand years ago (kya) and rapidly populated all of the New …

Genetic differentiation in South Amerindians is related to environmental and cultural diversity: evidence from the Y chromosome

E Tarazona-Santos, DR Carvalho-Silva… - The American Journal of …, 2001 - cell.com
The geographic structure of Y-chromosome variability has been analyzed in native
populations of South America, through use of the high-frequency Native American …

Mitochondrial DNA diversity in South America and the genetic history of Andean highlanders

S Fuselli, E Tarazona-Santos… - Molecular biology …, 2003 - academic.oup.com
We analyzed mtDNA sequence variation in 590 individuals from 18 south Amerindian
populations. The spatial pattern of mtDNA diversity in these populations fits well the model …

Arrival of Paleo-Indians to the southern cone of South America: new clues from mitogenomes

M de Saint Pierre, F Gandini, UA Perego, M Bodner… - PloS one, 2012 - journals.plos.org
With analyses of entire mitogenomes, studies of Native American mitochondrial DNA
(mtDNA) variation have entered the final phase of phylogenetic refinement: the dissection of …

Dissecting the pre-Columbian genomic ancestry of Native Americans along the Andes–Amazonia divide

GA Gnecchi-Ruscone, S Sarno… - Molecular biology …, 2019 - academic.oup.com
Abstract Extensive European and African admixture coupled with loss of Amerindian
lineages makes the reconstruction of pre-Columbian history of Native Americans based on …

Tracing the genomic ancestry of Peruvians reveals a major legacy of pre-Columbian ancestors

JR Sandoval, A Salazar-Granara, O Acosta… - Journal of human …, 2013 - nature.com
In order to investigate the underlying genetic structure and genomic ancestry proportions of
Peruvian subpopulations, we analyzed 551 human samples of 25 localities from the …

Land, language, and loci: mtDNA in Native Americans and the genetic history of Peru

CM Lewis Jr, RY Tito, B Lizarraga… - American Journal of …, 2005 - Wiley Online Library
Despite a long history of complex societies and despite extensive present‐day linguistic and
ethnic diversity, relatively few populations in Peru have been sampled for population genetic …