Bacteria provide a rich source of natural products with potential therapeutic applications,
such as novel antibiotic classes or anticancer drugs. Bioactivity-guided screening of …

Assembly-line polyketide synthases (PKSs) are among the most complex protein
machineries known in nature, responsible for the biosynthesis of numerous compounds …

Despite advances in sequencing, lack of standardization makes comparisons across studies
challenging and hampers insights into the structure and function of microbial communities …

Covering: up to 2021 Metagenomics has yielded massive amounts of sequencing data
offering a glimpse into the biosynthetic potential of the uncultivated microbial majority. While …

The growing problem of antibiotic resistance has led to the exploration of uncultured
bacteria as potential sources of new antimicrobials. PCR amplicon analyses and short-read …

Antibiotic resistance is becoming a burning issue due to the frequent use of antibiotics for
curing common bacterial infections, indicating that we are running out of effective antibiotics …

The heterologous expression of natural product biosynthetic gene clusters (BGCs) has
traditionally been used as a genetic platform to link various natural product chemotypes to …

The emergence of multidrug-resistant bacteria poses a threat to global health and
necessitates the development of additional in vivo active antibiotics with diverse modes of …

Bacteria produce diverse specialized metabolites that mediate ecological interactions and
serve as a rich source of industrially relevant natural products. Biosynthetic pathways for …

Microbial biosynthetic gene clusters (BGCs) encoding secondary metabolites are thought to
impact a plethora of biologically mediated environmental processes, yet their discovery and …