Deep learning-enabled virtual histological staining of biological samples

B Bai, X Yang, Y Li, Y Zhang, N Pillar… - Light: Science & …, 2023 - nature.com
Histological staining is the gold standard for tissue examination in clinical pathology and life-
science research, which visualizes the tissue and cellular structures using chromatic dyes or …

Artificial intelligence for digital and computational pathology

AH Song, G Jaume, DFK Williamson, MY Lu… - Nature Reviews …, 2023 - nature.com
Advances in digitizing tissue slides and the fast-paced progress in artificial intelligence,
including deep learning, have boosted the field of computational pathology. This field holds …

The importance of resource awareness in artificial intelligence for healthcare

Z Jia, J Chen, X Xu, J Kheir, J Hu, H Xiao… - Nature Machine …, 2023 - nature.com
Artificial intelligence and machine learning (AI/ML) models have been adopted in a wide
range of healthcare applications, from medical image computing and analysis to continuous …

Deep learning in breast cancer imaging: A decade of progress and future directions

L Luo, X Wang, Y Lin, X Ma, A Tan… - IEEE Reviews in …, 2024 - ieeexplore.ieee.org
Breast cancer has reached the highest incidence rate worldwide among all malignancies
since 2020. Breast imaging plays a significant role in early diagnosis and intervention to …

Sparse multi-modal graph transformer with shared-context processing for representation learning of giga-pixel images

R Nakhli, PA Moghadam, H Mi… - Proceedings of the …, 2023 - openaccess.thecvf.com
Processing giga-pixel whole slide histopathology images (WSI) is a computationally
expensive task. Multiple instance learning (MIL) has become the conventional approach to …

Deep 3D histology powered by tissue clearing, omics and AI

A Ertürk - Nature Methods, 2024 - nature.com
To comprehensively understand tissue and organism physiology and pathophysiology, it is
essential to create complete three-dimensional (3D) cellular maps. These maps require …

Virtual birefringence imaging and histological staining of amyloid deposits in label-free tissue using autofluorescence microscopy and deep learning

X Yang, B Bai, Y Zhang, M Aydin, Y Li… - Nature …, 2024 - nature.com
Systemic amyloidosis involves the deposition of misfolded proteins in organs/tissues,
leading to progressive organ dysfunction and failure. Congo red is the gold-standard …

Digital staining in optical microscopy using deep learning-a review

L Kreiss, S Jiang, X Li, S Xu, KC Zhou, KC Lee… - PhotoniX, 2023 - Springer
Until recently, conventional biochemical staining had the undisputed status as well-
established benchmark for most biomedical problems related to clinical diagnostics …

PhaseFIT: live-organoid phase-fluorescent image transformation via generative AI

J Zhao, X Wang, J Zhu, C Chukwudi… - Light: Science & …, 2023 - nature.com
Organoid models have provided a powerful platform for mechanistic investigations into
fundamental biological processes involved in the development and function of organs …

Topology-guided multi-class cell context generation for digital pathology

S Abousamra, R Gupta, T Kurc… - Proceedings of the …, 2023 - openaccess.thecvf.com
In digital pathology, the spatial context of cells is important for cell classification, cancer
diagnosis and prognosis. To model such complex cell context, however, is challenging …