Alterations in cortical interneurons and cognitive function in schizophrenia

SJ Dienel, DA Lewis - Neurobiology of disease, 2019 - Elsevier
Certain clinical features of schizophrenia, such as working memory disturbances, appear to
emerge from altered gamma oscillatory activity in the prefrontal cortex (PFC). Given the …

Auditory dysfunction in schizophrenia: integrating clinical and basic features

DC Javitt, RA Sweet - Nature Reviews Neuroscience, 2015 - nature.com
Schizophrenia is a complex neuropsychiatric disorder that is associated with persistent
psychosocial disability in affected individuals. Although studies of schizophrenia have …

Brain NMDA receptors in schizophrenia and depression

A Adell - Biomolecules, 2020 - mdpi.com
N-methyl-D-aspartate (NMDA) receptor antagonists such as phencyclidine (PCP),
dizocilpine (MK-801) and ketamine have long been considered a model of schizophrenia …

Differential alterations of auditory gamma oscillatory responses between pre-onset high-risk individuals and first-episode schizophrenia

M Tada, T Nagai, K Kirihara, S Koike, M Suga… - Cerebral …, 2016 - academic.oup.com
Alterations in gamma-band auditory steady-state response (ASSR) are the most robust
finding of abnormal neural oscillations in patients with first-episode (FES) and chronic …

Selective loss of smaller spines in schizophrenia

ML MacDonald, J Alhassan… - American Journal of …, 2017 - Am Psychiatric Assoc
Objective: Decreased density of dendritic spines in adult schizophrenia subjects has been
hypothesized to result from increased pruning of excess synapses in adolescence. In vivo …

Oligodendroglial alterations and the role of microglia in white matter injury: relevance to schizophrenia

LJ Chew, P Fusar-Poli, T Schmitz - Developmental neuroscience, 2013 - karger.com
Schizophrenia is a chronic and debilitating mental illness characterized by a broad range of
abnormal behaviors, including delusions and hallucinations, impaired cognitive function, as …

[HTML][HTML] 40-Hz auditory steady-state responses characterize circuit dysfunctions and predict clinical outcomes in clinical high-risk for psychosis participants: a …

T Grent, R Gajwani, J Gross, AI Gumley… - Biological …, 2021 - Elsevier
Background This study aimed to examine whether 40-Hz auditory steady-state responses
(ASSRs) are impaired in participants at clinical high-risk for psychosis (CHR-P) and predict …

Gamma-band auditory steady-state response as a neurophysiological marker for excitation and inhibition balance: a review for understanding schizophrenia and …

M Tada, K Kirihara, D Koshiyama… - Clinical EEG and …, 2020 - journals.sagepub.com
Altered gamma oscillations have attracted considerable attention as an index of the
excitation/inhibition (E/I) imbalance in schizophrenia and other neuropsychiatric disorders …

Loss of microtubule-associated protein 2 immunoreactivity linked to dendritic spine loss in schizophrenia

MA Shelton, JT Newman, H Gu, AR Sampson… - Biological …, 2015 - Elsevier
Background Microtubule-associated protein 2 (MAP2) is a neuronal protein that plays a role
in maintaining dendritic structure through its interaction with microtubules. In schizophrenia …

Activity-dependent synaptic plasticity modulates the critical phase of brain development

S Chaudhury, V Sharma, V Kumar, TC Nag… - Brain and …, 2016 - Elsevier
Plasticity or neuronal plasticity is a unique and adaptive feature of nervous system which
allows neurons to reorganize their interactions in response to an intrinsic or extrinsic …