Histone variants endow chromatin with unique properties and show a specific genomic
distribution that is regulated by specific deposition and removal machineries. These variants …

Chromatin compacts genomic DNA in eukaryotes. The primary chromatin unit is the
nucleosome core particle, composed of four pairs of the core histones, H2A, H2B, H3, and …

Chromosome instability is a critical event in cancer progression. Histone H3 variant CENP-A
plays a fundamental role in defining centromere identity, structure, and function but is …

Background The histone H3 variant CENP-A is normally tightly regulated to ensure only one
centromere exists per chromosome. Native CENP-A is often found overexpressed in human …

Centromeric chromatin undergoes major changes in composition and architecture during
each cell cycle. These changes in specialized chromatin facilitate kinetochore formation in …

Faithful chromosome segregation is essential for the maintenance of genomic integrity and
requires functional centromeres. Centromeres are epigenetically defined by the histone H3 …

Mutations of the Glu76 residue of canonical histone H2B are frequently found in cancer
cells. However, it is quite mysterious how a single amino acid substitution in one of the …

Centromeres are epigenetically determined chromosomal loci that seed kinetochore
assembly to promote chromosome segregation during cell division. CENP-A, a centromere …

In eukaryotes, genomic DNA is compacted in chromatin, which generally suppresses
transcription, replication, repair, and recombination. The fundamental unit of chromatin is the …

The histone H3 variant CENP-A is a crucial epigenetic marker for centromere specification.
CENP-A forms a characteristic nucleosome and dictates the higher-order configuration of …