Overview of OxLDL and its impact on cardiovascular health: focus on atherosclerosis

AV Poznyak, NG Nikiforov, AM Markin… - Frontiers in …, 2021 - frontiersin.org
Cardiovascular pathologies maintain the leading position in mortality worldwide.
Atherosclerosis is a chronic disease that can result in a variety of serious complications …

ROS: basic concepts, sources, cellular signaling, and its implications in aging pathways

AJPO de Almeida, JCPL de Oliveira… - Oxidative medicine …, 2022 - Wiley Online Library
Reactive oxygen species (ROS) are bioproducts of cellular metabolism. There is a range of
molecules with oxidizing properties known as ROS. Despite those molecules being implied …

Endothelial dysfunction due to eNOS uncoupling: Molecular mechanisms as potential therapeutic targets

A Janaszak-Jasiecka, A Płoska, JM Wierońska… - Cellular & molecular …, 2023 - Springer
Nitric oxide (NO) is one of the most important molecules released by endothelial cells, and
its antiatherogenic properties support cardiovascular homeostasis. Diminished NO …

[HTML][HTML] Sources of vascular nitric oxide and reactive oxygen species and their regulation

J Tejero, S Shiva, MT Gladwin - Physiological reviews, 2018 - journals.physiology.org
Nitric oxide (NO) is a small free radical with critical signaling roles in physiology and
pathophysiology. The generation of sufficient NO levels to regulate the resistance of the …

Endothelial cell metabolism

G Eelen, P de Zeeuw, L Treps, U Harjes… - Physiological …, 2018 - journals.physiology.org
Endothelial cells (ECs) are more than inert blood vessel lining material. Instead, they are
active players in the formation of new blood vessels (angiogenesis) both in health and (life …

[HTML][HTML] B vitamins and the brain: mechanisms, dose and efficacy—a review

DO Kennedy - Nutrients, 2016 - mdpi.com
The B-vitamins comprise a group of eight water soluble vitamins that perform essential,
closely inter-related roles in cellular functioning, acting as co-enzymes in a vast array of …

Endothelial cell metabolism in normal and diseased vasculature

G Eelen, P De Zeeuw, M Simons… - Circulation research, 2015 - Am Heart Assoc
Higher organisms rely on a closed cardiovascular circulatory system with blood vessels
supplying vital nutrients and oxygen to distant tissues. Not surprisingly, vascular pathologies …

New therapeutic implications of endothelial nitric oxide synthase (eNOS) function/dysfunction in cardiovascular disease

A Daiber, N Xia, S Steven, M Oelze, A Hanf… - International journal of …, 2019 - mdpi.com
The Global Burden of Disease Study identified cardiovascular risk factors as leading causes
of global deaths and life years lost. Endothelial dysfunction represents a pathomechanism …

[HTML][HTML] European contribution to the study of ROS: A summary of the findings and prospects for the future from the COST action BM1203 (EU-ROS)

J Egea, I Fabregat, YM Frapart, P Ghezzi, A Görlach… - Redox biology, 2017 - Elsevier
Abstract The European Cooperation in Science and Technology (COST) provides an ideal
framework to establish multi-disciplinary research networks. COST Action BM1203 (EU …

The adverse effects of environmental noise exposure on oxidative stress and cardiovascular risk

T Münzel, M Sørensen, F Schmidt… - Antioxidants & redox …, 2018 - liebertpub.com
Epidemiological studies have provided evidence that traffic noise exposure is linked to
cardiovascular diseases such as arterial hypertension, myocardial infarction, and stroke …