Cerebral malaria is a life-threatening complication of malaria infection. The pathogenesis of
cerebral malaria is poorly defined and progress in understanding the condition is severely …

Many human genetic associations with resistance to malaria have been reported, but few
have been reliably replicated. We collected data on 11,890 cases of severe malaria due to …

Populations exposed to Plasmodium infection develop genetic mechanisms of protection
against severe disease. The clinical manifestation of malaria results primarily from the lysis …

Abstract Background Susceptibility/resistance to Plasmodium falciparum malaria has been
correlated with polymorphisms in more than 30 human genes with most association …

Background Cerebral malaria is the most severe form of infection with Plasmodium
falciparum characterized by a highly inflammatory response. This systematic review aimed …

Background Tumour necrosis factor (TNF) and interferon gamma (IFN-γ), encoded by TNF-
836 C/A (rs 1800630) and IFN-γ-1616 C/T (rs2069705) genes, are key immunological …

The tumor necrosis factor gene (TNF) and lymphotoxin-α gene (LTA) have long attracted
attention as candidate genes for susceptibility traits for malaria, and several of their …

Multiple factors are involved in the variability of host's response to P. falciparum infection,
like the intensity and seasonality of malaria transmission, the virulence of parasite and host …

In Volume 1 of “Dynamic Models of Infectious Diseases,” ISBN 978-1-4614-3960-8 and 978-
1-4614-3961-5 (eBook), we assembled eight chapters from highly acclaimed international …

Malaria is a life-threatening blood disease caused by the protozoan Plasmodium. Infection
may lead to several different patterns of symptoms in the host: asymptomatic state …