The genomic signatures of Shigella evolution, adaptation and geographical spread

HC The, DP Thanh, KE Holt, NR Thomson… - Nature Reviews …, 2016 - nature.com
Shigella spp. are some of the key pathogens responsible for the global burden of diarrhoeal
disease. These facultative intracellular bacteria belong to the family Enterobacteriaceae …

Shigella flexneri: an emerging pathogen

I Nisa, M Qasim, N Yasin, R Ullah, A Ali - Folia microbiologica, 2020 - Springer
Shigella flexneri is a leading etiologic agent of diarrhea in low socioeconomic countries.
Notably, various serotypes in S. flexneri are reported from different regions of the world. The …

The variation of O antigens in gram-negative bacteria

L Wang, Q Wang, PR Reeves - Endotoxins: Structure, function and …, 2010 - Springer
The O antigen, consisting of many repeats of an oligosaccharide unit, is part of the
lipopolysaccharide (LPS) in the outer membrane of Gram-negative bacteria. It is on the cell …

Shigella flexneri O-antigens revisited: final elucidation of the O-acetylation profiles and a survey of the O-antigen structure diversity

AV Perepelov, ME Shekht, B Liu… - FEMS Immunology & …, 2012 - academic.oup.com
Shigella flexneri is an important human pathogen causing shigellosis. Strains of S. flexneri
are serologically heterogeneous and, based on O-antigens, are currently classified into 14 …

In Silico Serotyping Based on Whole-Genome Sequencing Improves the Accuracy of Shigella Identification

Y Wu, HK Lau, T Lee, DK Lau… - Applied and …, 2019 - Am Soc Microbiol
Bacteria of the genus Shigella, consisting of 4 species and> 50 serotypes, cause shigellosis,
a foodborne disease of significant morbidity, mortality, and economic loss worldwide …

O-Antigen modifications providing antigenic diversity of Shigella flexneri and underlying genetic mechanisms

YA Knirel, Q Sun, SN Senchenkova, AV Perepelov… - Biochemistry …, 2015 - Springer
O-Antigens (O-specific polysaccharides) of Shigella flexneri, a primary cause of shigellosis,
are distinguished by a wide diversity of chemical modifications following the oligosaccharide …

Functional Annotation and Curation of Hypothetical Proteins Present in A Newly Emerged Serotype 1c of Shigella flexneri: Emphasis on Selecting Targets for …

T Sen, NK Verma - Genes, 2020 - mdpi.com
Shigella flexneri is the principal cause of bacillary dysentery, contributing significantly to the
global burden of diarrheal disease. The appearance and increase in the multi-drug …

Development of a multiplex PCR assay targeting O-antigen modification genes for molecular serotyping of Shigella flexneri

Q Sun, R Lan, Y Wang, A Zhao, S Zhang… - Journal of clinical …, 2011 - Am Soc Microbiol
Shigella flexneri is the major Shigella species that causes diarrheal disease in developing
countries. It is further subdivided into 15 serotypes based on O-antigen structure. Serotyping …

Identification and Characterization of a Novel Shigella flexneri Serotype Yv in China

Q Sun, R Lan, J Wang, S Xia, Y Wang, Y Wang, D Jin… - PloS one, 2013 - journals.plos.org
Shigella flexneri is the major cause of bacterial shigellosis in developing countries. S.
flexneri is divided into at least 19 serotypes, the majority of which are modifications of the …

A Novel Plasmid-Encoded Serotype Conversion Mechanism through Addition of Phosphoethanolamine to the O-Antigen of Shigella flexneri

Q Sun, YA Knirel, R Lan, J Wang, SN Senchenkova… - 2012 - journals.plos.org
Shigella flexneri is the major pathogen causing bacillary dysentery in developing countries.
S. flexneri is divided into at least 16 serotypes based on the combination of antigenic …