At each of the brain's vast number of synapses, the presynaptic nerve terminal, synaptic cleft,
and postsynaptic specialization form a transcellular unit to enable efficient transmission of …

Synaptic vesicle recycling is one of the best‐studied cellular pathways. Many of the proteins
involved are known, and their interactions are becoming increasingly clear. However, as for …

The neuromuscular junction (NMJ) plays a fundamental role in transferring information from
lower motor neuron to skeletal muscle to generate movement. It is also an experimentally …

The commands that control animal movement are transmitted from motor neurons to their
target muscle cells at the neuromuscular junctions (NMJs). The NMJs contain many protein …

The regulated release of neurotransmitter occurs via the fusion of synaptic vesicles (SV s) at
specialized regions of the presynaptic membrane called active zones (AZ s). These regions …

The nanoscale topographical arrangement of voltage-gated calcium channels (VGCC) and
synaptic vesicles (SVs) determines synaptic strength and plasticity, but whether distinct …

Variance analysis of postsynaptic current amplitudes suggests the presence of distinct
docking sites (also called release sites) where vesicles pause before exocytosis. Docked …

Physical activity plays an important role in preventing chronic disease in adults and the
elderly. Exercise has beneficial effects on the nervous system, including at the …

Many central synapses contain a single presynaptic active zone and a single postsynaptic
density. Vesicular release statistics at such “simple synapses” indicate that they contain a …

Synaptic vesicles are organized in clusters, and synapsin maintains vesicle organization
and abundance in nerve terminals. At the functional level, vesicles can be subdivided into …