Colorectal liver metastasis: molecular mechanism and interventional therapy

H Zhou, Z Liu, Y Wang, X Wen, EH Amador… - Signal transduction and …, 2022 - nature.com
Colorectal cancer (CRC) is one of the most frequently occurring malignancy tumors with a
high morbidity additionally, CRC patients may develop liver metastasis, which is the major …

Metastasis organotropism in colorectal cancer: advancing toward innovative therapies

K He, Z Wang, M Luo, B Li, N Ding, L Li, B He… - Journal of Translational …, 2023 - Springer
Distant metastasis remains a leading cause of mortality among patients with colorectal
cancer (CRC). Organotropism, referring to the propensity of metastasis to target specific …

Acute stress response on Atlantic salmon: a time-course study of the effects on plasma metabolites, mucus cortisol levels, and head kidney transcriptome profile

A Madaro, J Nilsson, P Whatmore, HJ Roh… - Fish physiology and …, 2023 - Springer
Abstract Farmed Atlantic salmon (Salmo salar) welfare and performance can be strongly
influenced by stress episodes caused by handling during farming practices. To better …

Neuropilin 1 modulates TGF-β1-induced epithelial-mesenchymal transition in non-small cell lung cancer

Z Ding, W Du, Z Lei, Y Zhang… - International …, 2019 - spandidos-publications.com
Previously, the authors reported that neuropilin-1 (NRP1) was significantly increased and
acted as a vital promoter in the metastasis of non-small cell lung cancer (NSCLC). However …

Planarian EGF repeat-containing genes megf6 and hemicentin are required to restrict the stem cell compartment

N Lindsay-Mosher, A Chan, BJ Pearson - PLoS genetics, 2020 - journals.plos.org
The extracellular matrix (ECM) is important for maintaining the boundaries between tissues.
This role is particularly critical in the stem cell niche, as pre-neoplastic or cancerous stem …

Dynamic patterns of N6‐Methyladenosine profiles of messenger RNA correlated with the cardiomyocyte Regenerability during the early heart development in mice

Y Yang, S Shen, Y Cai, K Zeng, K Liu… - Oxidative medicine …, 2021 - Wiley Online Library
N6‐Methyladenosine (m6A) plays important roles in regulating mRNA processing. Despite
rapid progress in this field, little is known about the role and mechanism of m6A modification …

Rigorous evaluation of genetic and epigenetic effects on clinical laboratory measurements using Japanese monozygotic twins

J Taniguchi, T Masuda, Y Iwatani… - Clinical …, 2024 - Wiley Online Library
The investigation of environmental effects on clinical measurements using individual
samples is challenging because their genetic and environmental factors are different …

A role for the MEGF6 gene in predisposition to osteoporosis

CC Teerlink, MJ Jurynec, R Hernandez… - Annals of human …, 2021 - Wiley Online Library
Osteoporosis is a common skeletal disorder characterized by deterioration of bone tissue.
The set of genetic factors contributing to osteoporosis is not completely specified. High‐risk …

Copy number variation pattern for discriminating MACROD2 states of colorectal cancer subtypes

SQ Zhang, XY Pan, T Zeng, W Guo, Z Gan… - … in Bioengineering and …, 2019 - frontiersin.org
Copy number variation (CNV) is a common structural variation pattern of DNA, and it
features a higher mutation rate than single-nucleotide polymorphisms (SNPs) and affects a …

[HTML][HTML] Discovery of core gene families associated with liver metastasis in colorectal cancer and regulatory roles in tumor cell immune infiltration

WQ Liu, WL Li, SM Ma, L Liang, ZY Kou, J Yang - Translational Oncology, 2021 - Elsevier
In this study, we aimed to uncover genes that drive the pathogenesis of liver metastasis in
colorectal cancer (CRC), and identify effective genes that could serve as potential …