Transgenic zebrafish (Danio rerio) as an emerging model system in ecotoxicology and toxicology: Historical review, recent advances, and trends

RS Brito, A Canedo, D Farias, TL Rocha - Science of the Total Environment, 2022 - Elsevier
Zebrafish (Danio rerio) is an alternative model system for drug screening, developing new
products, and assessing ecotoxic effects of pollutants and biomonitor species in …

Zebrafish model in drug safety assessment

J Kanungo, E Cuevas, SF Ali… - Current pharmaceutical …, 2014 - ingentaconnect.com
Over the past decade, zebrafish are being increasingly used in assessing the effects of
chemical compounds. Especially, the embryos and larvae, due to their microscopically small …

Say no to DMSO: dimethylsulfoxide inactivates cisplatin, carboplatin, and other platinum complexes

MD Hall, KA Telma, KE Chang, TD Lee, JP Madigan… - Cancer research, 2014 - AACR
The platinum drugs cisplatin, carboplatin, and oxaliplatin are highly utilized in the clinic and
as a consequence are extensively studied in the laboratory setting. In this study, we …

Macrophage depletion protects against cisplatin-induced ototoxicity and nephrotoxicity

CYW Sung, N Hayase, PST Yuen, J Lee… - Science …, 2024 - science.org
Cisplatin is a widely used anticancer drug with notable side effects including ototoxicity and
nephrotoxicity. Macrophages, the major resident immune cells in the cochlea and kidney …

The role of Wnt/β‐catenin signaling in proliferation and regeneration of the developing basilar papilla and lateral line

BE Jacques, WH Montgomery IV… - Developmental …, 2014 - Wiley Online Library
Canonical Wnt/β‐catenin signaling has been implicated in multiple developmental events
including the regulation of proliferation, cell fate, and differentiation. In the inner ear, Wnt/β …

Sensory hair cell death and regeneration in fishes

JD Monroe, G Rajadinakaran, ME Smith - Frontiers in cellular …, 2015 - frontiersin.org
Sensory hair cells are specialized mechanotransductive receptors required for hearing and
vestibular function. Loss of hair cells in humans and other mammals is permanent and …

Toll‐like receptor 4 is activated by platinum and contributes to cisplatin‐induced ototoxicity

G Babolmorad, A Latif, IK Domingo, NM Pollock… - EMBO …, 2021 - embopress.org
Abstract Toll‐like receptor 4 (TLR4) recognizes bacterial lipopolysaccharide (LPS) and can
also be activated by some Group 9/10 transition metals, which is believed to mediate …

Luminescent cycloplatinated complexes with biologically relevant phosphine ligands: optical and cytotoxic properties

G Millán, N Giménez, R Lara, JR Berenguer… - Inorganic …, 2019 - ACS Publications
Two series of neutral luminescent pentafluorophenyl cycloplatinated (II) complexes [Pt (C^
N)(C6F5) L][C^ N= C-deprotonated 2-phenylpyridine (ppy; a), 2-(2, 4-difluorophenylpyridine …

Natural bizbenzoquinoline derivatives protect zebrafish lateral line sensory hair cells from aminoglycoside toxicity

M Kruger, R Boney, AJ Ordoobadi… - Frontiers in cellular …, 2016 - frontiersin.org
Moderate to severe hearing loss affects 360 million people worldwide and most often results
from damage to sensory hair cells. Hair cell damage can result from aging, genetic …

Sustained drug delivery of doxorubicin as a function of pH, releasing media, and NCO contents in polyurethane urea elastomers

M Shoaib, A Bahadur, MS ur Rahman, S Iqbal… - Journal of Drug Delivery …, 2017 - Elsevier
Abstract A novel diamine 4-(4-aminophenoxy) butyl-4-aminophenyl ether (ABAE) was
synthesized as a chain extender (CE) by a quick and facile method using microwave reactor …