The increasing incidence of diseases affecting the central nervous system (CNS) demands
the urgent development of efficient drugs. While many of these medicines are already …

The delivery of therapeutic nucleic acids to neurons has the potential to treat neurological
disease and spinal cord injury. While select viral vectors have shown promise as gene …

The urea cycle is strongly implicated in the pathogenesis of Alzheimer's disease (AD).
Arginase-I (ARGI) accumulation at sites of amyloid-beta (Aβ) deposition is associated with L …

Lack of targeting and improper biodistribution are major flaws in current drug-based
therapies that prevent reaching high local concentrations of the therapeutic agent. Such …

Non-viral gene therapy uses engineered nanoparticles in the virus size range for the cell-
targeted delivery of therapeutic nucleic acids. A diverse range of macromolecules are …

The construction of non-viral, virus-like vehicles for gene therapy involves the
functionalization of multipartite constructs with nucleic acid-binding, cationic agents. Short …

Preconditioning by brief ischemic episode induces tolerance to a subsequent lethal
ischemic insult, and it has been suggested that reactive oxygen species are involved in this …

Growing evidence highlights the role of arginase activity in the manifestation of Alzheimer's
disease (AD). Upregulation of arginase was shown to contribute to neurodegeneration …

Neonatal anesthesia, while often essential for surgeries or imaging procedures, is
accompanied by significant risks to redox balance in the brain due to the relatively weak …

Ji, Weizhong, Yaqing Zhang, Ri-li Ge, Yaqi Wan, and Jie Liu. NMDA receptor-mediated
excitotoxicity is involved in neuronal apoptosis and cognitive impairment induced by chronic …