Hydroxytyrosol: Bioavailability, toxicity, and clinical applications

M Robles-Almazan, M Pulido-Moran… - Food Research …, 2018 - Elsevier
Many beneficial properties have been attributed to the Mediterranean diet. Over the years,
researchers have attempted to learn which foods and which food components are …

Obesity and aging: Molecular mechanisms and therapeutic approaches

AL Santos, S Sinha - Ageing Research Reviews, 2021 - Elsevier
The epidemic of obesity is a major challenge for health policymakers due to its far-reaching
effects on population health and potentially overwhelming financial burden on healthcare …

Nutraceutical properties of olive oil polyphenols. An itinerary from cultured cells through animal models to humans

S Rigacci, M Stefani - International journal of molecular sciences, 2016 - mdpi.com
The increasing interest in the Mediterranean diet hinges on its healthy and anti-ageing
properties. The composition of fatty acids, vitamins and polyphenols in olive oil, a key …

Potential uses of olive oil secoiridoids for the prevention and treatment of cancer: a narrative review of preclinical studies

MR Emma, G Augello, V Di Stefano, A Azzolina… - International journal of …, 2021 - mdpi.com
The Mediterranean diet (MD) is a combination of foods mainly rich in antioxidants and anti-
inflammatory nutrients that have been shown to have many health-enhancing effects. Extra …

Potential Protective Role Exerted by Secoiridoids from Olea europaea L. in Cancer, Cardiovascular, Neurodegenerative, Aging-Related, and Immunoinflammatory …

ML Castejón, T Montoya, C Alarcón-de-la-Lastra… - Antioxidants, 2020 - mdpi.com
Iridoids, which have beneficial health properties, include a wide group of cyclopentane [c]
pyran monoterpenoids present in plants and insects. The cleavage of the cyclopentane ring …

Antitumor perspectives of oleuropein and its metabolite hydroxytyrosol: Recent updates

M Imran, M Nadeem, SA Gilani, S Khan… - Journal of food …, 2018 - Wiley Online Library
Olive fruit is a significant and promising source of potential bioactive compounds such as
oleuropein and hydroxytyrosol. Oleuropein is the ester of elenolic acid and 3, 4 …

Oleuropein: Chemistry, extraction techniques and nutraceutical perspectives-An update

AA Khalil, MM Rahman, A Rauf, MR Islam… - Critical Reviews in …, 2024 - Taylor & Francis
Olive family (Oleaceae) contains several species among which Olea europaea L. is mostly
used for production of olive oils. Various parts of olive tree are rich source of diverse …

Anticancer effects of oleuropein

H Shamshoum, F Vlavcheski, E Tsiani - Biofactors, 2017 - Wiley Online Library
Cancer cells exhibit enhanced proliferation rate and a resistance to apoptosis.
Epidemiological studies suggest that olive oil intake is associated with a reduced risk of …

Oleuropein, the Main Polyphenol of Olea europaea Leaf Extract, Has an Anti-Cancer Effect on Human BRAF Melanoma Cells and Potentiates the Cytotoxicity of …

J Ruzzolini, S Peppicelli, E Andreucci, F Bianchini… - Nutrients, 2018 - mdpi.com
Oleuropein (Ole), a secoiridoid glucoside present in Olea europaea leaves, gained scientific
interest thanks to its several biological properties, including the anticancer one. We verified …

Hydroxytyrosol and potential uses in cardiovascular diseases, cancer, and AIDS

C Vilaplana-Pérez, D Auñón, LA García-Flores… - Frontiers in …, 2014 - frontiersin.org
Hydroxytyrosol is one of the main phenolic components of olive oil. It is present in the fruit
and leaf of the olive (Olea europaea L.). During the past decades, it has been well …