Opioids are widely prescribed for pain management, and it is estimated that 40% of adults in
the United States use prescription opioids every year. Opioid misuse leads to high mortality …

This paper is the fortieth consecutive installment of the annual anthological review of
research concerning the endogenous opioid system, summarizing articles published during …

Synthetic opioids like fentanyl have improved the standard of care for many patients in the
clinical setting, but their abuse leads to tens of thousands of overdose deaths annually. The …

Death from opioid overdose is typically caused by opioid-induced respiratory depression
(OIRD). A particularly dangerous characteristic of OIRD is its apparent unpredictability. The …

In vitro and in vivo anesthetized studies led to the conclusion that “deficiencies in one
neuromodulator are immediately compensated by the action of other neuromodulators,” …

In vitro and in vivo anesthetized studies led to the conclusion that “deficiencies in one 50
neuromodulator are immediately compensated by the action of other neuromodulators” …

A cirrose hepática é condição de grande impacto na saúde mundial, e persiste entre as dez
maiores causas de morte em países desenvolvidos, com 38,170 mortes atribuíveis à cirrose …

Opioids are used routinely for acute and chronic pain management, as an adjunct to
anaesthesia and to manage opioid dependence. Low-dose morphine is the only evidence …