Telomeres, the ends of linear eukaryotic chromosomes, are characterized by the presence
of multiple repeats of a short DNA sequence. This telomeric DNA is protected from illicit …

Ku is an abundant, highly conserved DNA binding protein found in both prokaryotes and
eukaryotes that plays essential roles in the maintenance of genome integrity. In eukaryotes …

DNA double-strand breaks (DSBs) are accidental lesions generated by various endogenous
or exogenous stresses. DSBs are also genetically programmed events during the V (D) J …

Telomeres are the physical ends of eukaryotic linear chromosomes. Telomeres form special
structures that cap chromosome ends to prevent degradation by nucleolytic attack and to …

Telomeres are nucleoprotein structures that cap the ends of the linear eukaryotic
chromosomes and thereby protect their stability and integrity. Telomeres play central roles in …

Telomerase maintains chromosome ends from humans to yeasts. Recruitment of yeast
telomerase to telomeres occurs through its Ku and Est1 subunits via independent …

DNA double strand breaks (DSBs) are dangerous sources of genome instability and must be
repaired by the cell. Nonhomologous end-joining (NHEJ) is an evolutionarily conserved …

Summary In Saccharomyces cerevisiae, the Ku heterodimer contributes to telomere
maintenance as a component of telomeric chromatin and as an accessory subunit of …

Telomeres are protected from nonhomologous end-joining (NHEJ) to avoid deleterious
chromosome fusions, yet they associate with the Ku heterodimer that is principal in the …

Single-stranded telomeric DNA protrusions are considered to be evolutionarily conserved
structural elements essential for chromosome end protection. Their formation at telomeres …