Despite the ability of peripheral nerves to spontaneously regenerate after injury, recovery is
generally very poor. The neurotrophins have emerged as an important modulator of axon …

Background: Peripheral nerve injuries remain a major clinical concern, as they often lead to
chronic disability and significant health care expenditures. Despite advancements in …

Neural injury in mammals often leads to persistent functional deficits as spontaneous repair
in the peripheral nervous system (PNS) is often incomplete, while endogenous repair …

Injured peripheral nerves typically exhibit unsatisfactory and incomplete functional
outcomes, and there are no clinically approved therapies for improving regeneration. Post …

With the rise of optogenetic manipulation of neurons, the effects of optogenetic heating on
temperature-sensitive physiological processes, and the damage to surrounding tissues have …

Enhancing axon regeneration is a major focus of nerve injury research, and the quality of the
surgical nerve repair plays a large role in the aggregate success of nerve regeneration …

The successful introduction of innovative treatment strategies into clinical practise strongly
depends on the availability of effective experimental models and their reliable pre-clinical …

Optogenetics has recently gained recognition as a biological technique to control the activity
of cells using light stimulation. Many studies have applied optogenetics to cell lines in the …

Introduction—Recovery from peripheral nerve injuries is poor even though injured
peripheral axons can regenerate. Novel therapeutic approaches are needed. The most …

Dysfunction of neuronal circuits is an important determinant of neurodegenerative diseases.
Synaptic dysfunction, death, and intrinsic activity of neurons are thought to contribute to the …