Cross-talk between IL-6 trans-signaling and AIM2 inflammasome/IL-1β axes bridge innate immunity and epithelial apoptosis to promote emphysema

SM Ruwanpura, L McLeod… - Proceedings of the …, 2022 - National Acad Sciences
Pulmonary emphysema is associated with dysregulated innate immune responses that
promote chronic pulmonary inflammation and alveolar apoptosis, culminating in lung …

Smoking and tetramer tryptase accelerate intervertebral disc degeneration by inducing METTL14-mediated DIXDC1 m6 modification

J Tu, W Li, PM Hansbro, Q Yan, X Bai, C Donovan… - Molecular Therapy, 2023 - cell.com
Although cigarette smoking (CS) and low back pain (LBP) are common worldwide, their
correlations and the mechanisms of action remain unclear. We have shown that excessive …

Activation of the AIM2 receptor in circulating cells of post-COVID-19 patients with signs of lung fibrosis is associated with the release of IL-1α, IFN-α and TGF-β

C Colarusso, M Terlizzi, A Maglio, A Molino… - Frontiers in …, 2022 - frontiersin.org
Severe acute respiratory syndrome-coronavirus-2 (SARS‐CoV‐2), responsible for COVID-
19, has caused a global pandemic. Observational studies revealed a condition, herein …

[HTML][HTML] The Current Molecular and Cellular Landscape of Chronic Obstructive Pulmonary Disease (COPD): A Review of Therapies and Efforts towards Personalized …

LA Farrell, MB O'Rourke, MP Padula… - Proteomes, 2024 - mdpi.com
Chronic obstructive pulmonary disease (COPD) ranks as the third leading cause of global
illness and mortality. It is commonly triggered by exposure to respiratory irritants like …

Cigarette smoke components modulate the MR1–MAIT axis

W Awad, JR Mayall, W Xu, MD Johansen… - Journal of Experimental …, 2025 - rupress.org
Tobacco smoking is prevalent across the world and causes numerous diseases. Cigarette
smoke (CS) compromises immunity, yet little is known of the components of CS that impact T …

Neutrophils in toxicology: a forgotten field

P Scharf, M Aschner, S Farsky - Journal of Toxicology and …, 2024 - Taylor & Francis
Neutrophils are the most abundant leukocytes in humans and essential for innate immune
responses despite a short lifespan in the bloodstream. A complex and tightly regulated …

[HTML][HTML] Absent in melanoma 2 (AIM2) positive profile identifies a poor prognosis of lung adenocarcinoma patients

C Colarusso, M Terlizzi, A Falanga… - International …, 2023 - Elsevier
The absent in melanoma 2 (AIM2) inflammasome has been demonstrated as involved in
tumor growth. In this study we used human samples of lung adenocarcinoma (LUAD) …

The influence of pyroptosis-related genes on the development of chronic obstructive pulmonary disease

X Liu, X Huang, F Xu - BMC Pulmonary Medicine, 2023 - Springer
Increasing evidences have demonstrated that pyroptosis exerts key roles in the occurrence,
development of chronic obstructive pulmonary disease. However, the mechanisms of …

Maternal thirdhand exposure to e-cigarette vapor alters lung and bone marrow immune cell responses in offspring in the absence or presence of influenza infection

C Donovan, AE Thorpe, R Yarak… - … of Physiology-Lung …, 2024 - journals.physiology.org
There is increasing evidence that thirdhand exposure to e-cigarette vapor (e-vapor) can
have detrimental effects on the lungs. However, whether maternal exposure during …

Landscape fire smoke airway exposure impairs respiratory and cardiac function and worsens experimental asthma

HM Gomez, TJ Haw, D Ilic, P Robinson… - Journal of Allergy and …, 2024 - Elsevier
Background Millions of people are exposed to landscape fire smoke (LFS) globally, and
inhalation of LFS particulate matter (PM) is associated with poor respiratory and …