Macrocephaly affects up to 5% of the pediatric population and is defined as an abnormally
large head with an occipitofrontal circumference (OFC)> 2 standard deviations (SD) above …

Macrocephaly frequently occurs in single-gene disorders affecting the PI3K-AKT-MTOR
pathway; however, epigenetic mutations, mosaicism, and copy number variations (CNVs) …

The central nervous system (CNS) is composed of the brain and the spinal cord. They both
develop from the embryonic ectoderm alongside other structures like the skin. Their …

Macrocephaly is present in about 2–5% of the general population. It can be found as an
isolated benign trait or as part of a syndromic condition. Brain overgrowth has been …

Neurodevelopmental disorders (NDDs) are mostly diagnosed around the age of 4–5 years,
which is too late considering that the brain is most susceptive to interventions during the first …

Macrocephaly has been associated with neurodevelopmental disorders; however, it has
been mainly studied in the context of pathological or high-risk populations and little is known …

Background Macrocephaly is a common finding in infants and is often idiopathic or familial.
In the absence of clinical signs and symptoms, it can be difficult to determine when concern …

Background Macrocephaly is a clinical observation denoted as an occipitofrontal head
circumference exceeding two standard deviations above same age and sex norms. By its …

Macrocephaly is a frequently encountered entity within the pediatric clinical practice,
affecting approximately 2% to 5% of the population. It is diagnosed primarily in infants in …

Серйозні уроджені аномалії трапляються у 1 з 33 новонароджених або близько 125 000
живонароджених щорічно в США і є основною причиною дитячої смертності. Черепно …