It is well established that adipose tissue, apart from its energy storage function, acts as an
endocrine organ that produces and secretes a number of bioactive substances, including …

Metabolic syndrome (MetS) is a precursor to the major health diseases associated with high
mortality in industrialized countries: cardiovascular disease and diabetes. An important …

Background Mitochondria play an important role in cellular metabolism, and their
dysfunction is postulated to be involved in metabolic disturbances. Mitochondrial DNA is …

Over the past 4 decades, research has shown that having a normal body weight does not
automatically imply preserved metabolic health and a considerable number of lean …

Results Oxidative stress developed during obesity contributes to the formation of
peroxynitrite, which causes cytochrome C-related damage in the mitochondrial electron …

Mitochondrial DNA (mtDNA) encodes core subunits of oxidative phosphorylation complexes
and, as a result of intricate regulatory crosstalk between nuclear and mitochondrial …

The retinal pigment epithelium (RPE) acts as a metabolic gatekeeper between
photoreceptors and the choroidal vasculature to maintain retinal function. RPE dysfunction is …

Chronic inflammation may not begin with local tissue disorders, such as hypoxia, but with
the accumulation of critically activated macrophages in one site. The purpose of this review …

The past thirty years have seen a surge in interest in pathophysiological roles of
mitochondria, and the accurate quantification of mitochondrial DNA copy number (mCN) in …

Background Since both genomic and environmental factors are involved in obesity etiology,
several studies about the influence of adiposity on both nuclear DNA and mitochondrial …