In 2013 we established a cryo-electron microscopy (cryo-EM) technique called microcrystal
electron diffraction (MicroED). Since that time, data collection and analysis schemes have …

Metabotropic glutamate receptors are class C G-protein-coupled receptors which respond to
the neurotransmitter glutamate. Structural studies have been restricted to the amino-terminal …

We demonstrate that it is feasible to determine high-resolution protein structures by electron
crystallography of three-dimensional crystals in an electron cryo-microscope (CryoEM) …

Several systems, including contractile tail bacteriophages, the type VI secretion system and
R-type pyocins, use a multiprotein tubular apparatus to attach to and penetrate host cell …

Structural analysis of class B G-protein-coupled receptors (GPCRs), cell-surface proteins
that respond to peptide hormones, has been restricted to the amino-terminal extracellular …

During the early stages of infection, the HIV-1 capsid protects viral components from
cytosolic sensors and nucleases such as cGAS and TREX, respectively, while allowing …

Cytochrome P450 aromatase (AROM) and steroid sulfatase (STS) are the two key enzymes
for the biosynthesis of estrogens in human, and maintenance of the critical balance between …

Six novel Zr (IV)-and Hf (IV)-based MOFs, namely DUT-67, DUT-68, and DUT-69 (DUT,
Dresden University of Technology) were obtained using a modulated synthesis approach …

The design of functional membrane proteins from first principles represents a grand
challenge in chemistry and structural biology. Here, we report the design of a membrane …

The hemagglutinin (HA) of influenza A (H3N2) virus responsible for the 1968 influenza
pandemic derived from an avian virus. On introduction into humans, its receptor binding …