Biological membranes are key elements for the maintenance of cell architecture and
physiology. Beyond a pure barrier separating the inner space of the cell from the outer, the …

The lipid composition of cellular organelles is tailored to suit their specialized tasks. A
fundamental transition in the lipid landscape divides the secretory pathway in early and late …

Biomembranes are complex materials composed of lipids and proteins that
compartmentalize biochemistry. They are actively remodeled in response to physical and …

The endoplasmic reticulum (ER) is the major site of membrane biogenesis in most
eukaryotic cells. As the entry point to the secretory pathway, it handles more than 10,000 …

Biological membranes have a stunning ability to adapt their composition in response to
physiological stress and metabolic challenges. Little is known how such perturbations affect …

The composition of the plasma membrane (PM) must be tightly controlled despite constant,
rapid endocytosis, which requires active, selective recycling of endocytosed membrane …

The Golgi complex is the membrane-bound organelle that lies at the center of the secretory
pathway. Its main functions are to maintain cellular lipid homeostasis, to orchestrate protein …

Sphingomyelin is a dominant sphingolipid in mammalian cells. Its production in the trans-
Golgi traps cholesterol synthesized in the ER to promote formation of a sphingomyelin/sterol …

The order of enzymatic activity across Golgi cisternae is essential for complex molecule
biosynthesis. However, an inability to separate Golgi cisternae has meant that the cisternal …

Protein S‐acylation, also known as palmitoylation, consists of the addition of a lipid molecule
to one or more cysteine residues through a thioester bond. This modification, which is …