Rhoptries are specialized secretory organelles found in the Apicomplexa phylum, playing a
central role in the establishment of parasitism. The rhoptry content includes membranous as …

Toxoplasma gondii is an obligate intracellular parasite that can infect virtually any nucleated
cell. During invasion Toxoplasma creates the parasitophorous vacuole, a subcellular …

Malaria control demands the development of a wide range of complementary strategies. We
describe the properties of a naturally occurring, non–genetically modified symbiotic …

Examining host–pathogen interactions in animals can capture aspects of infection that are
obscured in cell culture. Using CRISPR-based screens, we functionally profile the entire …

Apicomplexan parasite growth and replication relies on nutrient acquisition from host cells,
in which intracellular multiplication occurs, yet the mechanisms that underlie the nutrient …

Sexual reproduction of Toxoplasma gondii, confined to the felid gut, remains largely
uncharted owing to ethical concerns regarding the use of cats as model organisms …

Rhoptries are specialized secretory organelles that are uniquely present within protozoan
parasites of the phylum Apicomplexa. These obligate intracellular parasites comprise some …

The intracellular compartment harboring Toxoplasma gondii satisfies the parasite's
nutritional needs for rapid growth in mammalian cells. We demonstrate that the …

Toxoplasma gondii is an obligate intracellular parasite and an important human pathogen.
Relatively little is known about the proteins that orchestrate host cell invasion by T. gondii or …

Recent years have seen tremendous progress in our understanding of malaria parasite
molecular biology. To a large extent, this progress follows significant developments in …