Type i DNA topoisomerases
G Capranico, J Marinello… - Journal of medicinal …, 2017 - ACS Publications
DNA topoisomerases constitute a large family of enzymes that are essential for all domains
of life. Although they share general reaction chemistry and the capacity to govern DNA …
of life. Although they share general reaction chemistry and the capacity to govern DNA …
Natural compounds as therapeutic agents: The case of human topoisomerase ib
A Ottaviani, F Iacovelli, P Fiorani… - International Journal of …, 2021 - mdpi.com
Natural products are widely used as source for drugs development. An interesting example
is represented by natural drugs developed against human topoisomerase IB, a ubiquitous …
is represented by natural drugs developed against human topoisomerase IB, a ubiquitous …
A kinetic clutch governs religation by type IB topoisomerases and determines camptothecin sensitivity
Y Seol, H Zhang, Y Pommier… - Proceedings of the …, 2012 - National Acad Sciences
Type IB topoisomerases (Top1Bs) relax excessive DNA supercoiling associated with
replication and transcription by catalyzing a transient nick in one strand to permit controlled …
replication and transcription by catalyzing a transient nick in one strand to permit controlled …
Simulations of DNA topoisomerase 1B bound to supercoiled DNA reveal changes in the flexibility pattern of the enzyme and a secondary protein–DNA binding site
Human topoisomerase 1B has been simulated covalently bound to a negatively supercoiled
DNA minicircle, and its behavior compared to the enzyme bound to a simple linear DNA …
DNA minicircle, and its behavior compared to the enzyme bound to a simple linear DNA …
Structural and dynamical effects induced by the anticancer drug topotecan on the human topoisomerase I–DNA complex
Background Human topoisomerase I catalyzes the relaxation of DNA supercoils in
fundamental cell processes like transcription, replication and chromosomal segregation. It is …
fundamental cell processes like transcription, replication and chromosomal segregation. It is …
From Antarctica to cancer research: a novel human DNA topoisomerase 1B inhibitor from Antarctic sponge Dendrilla antarctica
A Ottaviani, J Welsch, K Agama… - Journal of Enzyme …, 2022 - Taylor & Francis
Nature has been always a great source of possible lead compounds to develop new drugs
against several diseases. Here we report the identification of a natural compound …
against several diseases. Here we report the identification of a natural compound …
Molecular mechanism of the camptothecin resistance of Glu710Gly topoisomerase IB mutant analyzed in vitro and in silico
C Tesauro, B Morozzo della Rocca, A Ottaviani… - Molecular cancer, 2013 - Springer
Background DNA topoisomerases are key enzymes that modulate the topological state of
DNA through the breaking and rejoining of DNA strands. Human topoisomerase IB can be …
DNA through the breaking and rejoining of DNA strands. Human topoisomerase IB can be …
Distribution bias and biochemical characterization of TOP1MT single nucleotide variants
Abstract Mitochondrial topoisomerase I (TOP1MT) is a type IB topoisomerase encoded in the
nucleus of vertebrate cells. In contrast to the other five human topoisomerases, TOP1MT …
nucleus of vertebrate cells. In contrast to the other five human topoisomerases, TOP1MT …
Topoisomerase 1B as a target against leishmaniasis
I D'Annessa, S Castelli… - Mini Reviews in Medicinal …, 2015 - ingentaconnect.com
Leishmaniasis affects more than 12 million people in 98 countries, the infection being
caused by more than 20 species of protozoan parasites belonging to the genus Leishmania …
caused by more than 20 species of protozoan parasites belonging to the genus Leishmania …
In vitro and in silico characterization of an antimalarial compound with antitumor activity targeting human DNA topoisomerase IB
BC Soren, J Babu Dasari, A Ottaviani… - International Journal of …, 2021 - mdpi.com
Human DNA topoisomerase IB controls the topological state of supercoiled DNA through a
complex catalytic cycle that consists of cleavage and religation reactions, allowing the …
complex catalytic cycle that consists of cleavage and religation reactions, allowing the …