Apoptosis is a form of regulated cell death (RCD) that involves proteases of the caspase
family. Pharmacological and genetic strategies that experimentally inhibit or delay apoptosis …

During aging, the cellular milieu of the brain exhibits tell-tale signs of compromised
bioenergetics, impaired adaptive neuroplasticity and resilience, aberrant neuronal network …

Microglia are brain-resident myeloid cells that mediate key functions to support the CNS.
Microglia express a wide range of receptors that act as molecular sensors, which recognize …

Alzheimer's disease (AD) is a progressive neurodegenerative disorder of the brain, which is
characterized by the formation of extracellular amyloid plaques (or senile plaques) and …

Abstract Tumor Necrosis Factor (TNF), initially known for its tumor cytotoxicity, is a potent
mediator of inflammation, as well as many normal physiological functions in homeostasis …

Tauopathies are a broad set of neurodegenerative dementias characterized by aggregation
of the tau protein into filamentous inclusions that can be found in neurons and glial cells …

Alzheimer's disease (AD) affects an estimated 44 million individuals worldwide, yet no
therapeutic intervention is available to stop the progression of the dementia …

Aging is the leading risk factor for several age-associated diseases such as
neurodegenerative diseases. Understanding the biology of aging mechanisms is essential …

Alzheimer Disease (AD) is a neurodegenerative disorder and the most common form of
dementia. Histopathologically is characterized by the presence of two major hallmarks, the …

Tumor necrosis factor α (TNF-α) plays a central role in the pathophysiology of Alzheimer's
disease (AD). Food and Drug Administration–approved biologic TNF-α inhibitors are thus a …