Genome sequencing projects have resulted in a rapid increase in the number of known
protein sequences. In contrast, only about one-hundredth of these sequences have been …

Loops are key components of protein structures, involved in many biological functions. Due
to their conformational variability, the structural investigation of loops is a difficult topic …

The inhibition of protein–protein interactions is a growing strategy in drug development. In
addition to structured regions, many protein loop regions are involved in protein–protein …

The development of computational strategies for the quantitative characterization of the
functional mechanisms of SARS-CoV-2 spike proteins is of paramount importance in efforts …

Author summary The purpose of this quick guide is to help new modelers who have little or
no background in comparative modeling yet are keen to produce high-resolution protein 3D …

The natural immune repertoire can be a useful guide to antibody discovery against any
given target. However, the large volume of immunoglobulin gene sequencing data …

Inherited bleeding disorders such as Glanzmann thrombasthenia (GT) lack prophylactic
treatment options. As a result, serious bleeding episodes are treated acutely with blood …

Peptides have recently regained interest as therapeutic candidates, but their development
remains confronted with several limitations including low bioavailability. Backbone head-to …

The MD simulation package Amber offers an attractive platform to refine crystallographic
structures of proteins:(i) state-of-the-art force fields help to regularize protein coordinates …

Streptococcus pyogenes can cause invasive disease with high mortality despite adequate
antibiotic treatments. To address this unmet need, we have previously generated an opsonic …