All endocrine glands are susceptible to neoplastic growth, yet the health consequences of
these neoplasms differ between endocrine tissues. Pituitary neoplasms are highly prevalent …

The initiation and maintenance of reproductive capacity in humans is dependent on pulsatile
secretion of the hypothalamic hormone GnRH. Congenital hypogonadotropic hypogonadism …

Growth hormone (GH) deficiency (GHD) in children is defined as impaired production of GH
by the pituitary gland that results in growth failure. This disease might be congenital or …

The adenohypophysis (anterior pituitary) is a major centre for systemic hormones. At
present, no efficient stem-cell culture for its generation is available, partly because of …

A mechanistic connection between aging and development is largely unexplored. Through
profiling age-related chromatin and transcriptional changes across 22 murine cell types …

Sox2+ adult mouse pituitary cells can self-renew and terminally differentiate in vitro, but their
physiological role in vivo and possible contribution to oncogenesis remain largely unknown …

The genetic basis for combined pituitary hormone deficiency (CPHD) is complex, involving
30 genes in a variety of syndromic and nonsyndromic presentations. Molecular diagnosis of …

Anterior pituitary is critical for endocrine systems. Its hormonal responses to positive and
negative regulators are indispensable for homeostasis. For this reason, generating human …

Introduction: The developmental origins of disease or fetal programming model predicts that
intrauterine exposures have life long consequences for physical and psychological health …

Ocular lens development represents an advantageous system in which to study regulatory
mechanisms governing cell fate decisions, extracellular signaling, cell and tissue …