Environmental monitoring and the developmental origins of health and disease

DL Almeida, A Pavanello, LP Saavedra… - … origins of health and …, 2019 - cambridge.org
Early-life chronic exposure to environmental contaminants, such as bisphenol-A, particulate
matter air pollution, organophosphorus pesticides, and pharmaceutical drugs, among …

Animal Foetal models of obesity and diabetes–from laboratory to clinical settings

E Grzęda, J Matuszewska, K Ziarniak… - Frontiers in …, 2022 - frontiersin.org
The prenatal period, during which a fully formed newborn capable of surviving outside its
mother's body is built from a single cell, is critical for human development. It is also the time …

Maternal diet-induced obesity during suckling period programs offspring obese phenotype and hypothalamic leptin/insulin resistance

RM Gomes, FG Bueno, CR Schamber… - The Journal of nutritional …, 2018 - Elsevier
During the early post-natal period, offspring are vulnerable to environmental insults, such as
nutritional and hormonal changes, which increase risk to develop metabolic diseases later …

Maternal low-protein diet on the last week of pregnancy contributes to insulin resistance and β-cell dysfunction in the mouse offspring

EU Alejandro, S Jo, B Akhaphong… - American Journal …, 2020 - journals.physiology.org
Maternal low-protein diet (LP) throughout gestation affects pancreatic β-cell fraction of the
offspring at birth, thus increasing their susceptibility to metabolic dysfunction and type 2 …

Perinatal programming of metabolic diseases: the role of glucocorticoids

JC Facchi, TAL de Lima, LR de Oliveira… - Metabolism, 2020 - Elsevier
The worldwide increase in metabolic diseases has urged the scientific community to
improve our understanding about the mechanisms underlying its cause and effects. A well …

[HTML][HTML] The clandestine organs of the endocrine system

N Garcia-Reyero - General and comparative endocrinology, 2018 - Elsevier
This review analyzes what could be regarded as the “clandestine organs” of the endocrine
system: the gut microbiome, the immune system, and the stress system. The immune system …

Programming of vascular dysfunction by maternal stress: Immune system implications

TJ Costa, JC De Oliveira, FR Giachini, VV Lima… - Frontiers in …, 2022 - frontiersin.org
A growing body of evidence highlights that several insults during pregnancy impact the
vascular function and immune response of the male and female offspring. Overactivation of …

Acephate exposure during a perinatal life program to type 2 diabetes

TA Ribeiro, KV Prates, A Pavanello, A Malta, LP Tófolo… - Toxicology, 2016 - Elsevier
Acephate has been used extensively as an insecticide in agriculture. Its downstream
sequelae are associated with hyperglycemia, lipid metabolism dysfunction, DNA damage …

Impairment of microvascular angiogenesis is associated with delay in prostatic development in rat offspring of maternal protein malnutrition

KT Colombelli, SAA Santos, ACL Camargo… - General and …, 2017 - Elsevier
Experimental data demonstrated the negative impact of maternal protein malnutrition (MPM)
on rat prostate development, but the mechanism behind the impairment of prostate growth …

Maternal stress and diet may influence affective behavior and stress-response in offspring via epigenetic regulation of central peptidergic function

A Thorsell, D Nätt - Environmental epigenetics, 2016 - academic.oup.com
It has been shown that maternal stress and malnutrition, or experience of other adverse
events, during the perinatal period may alter susceptibility in the adult offspring in a time-of …