Mesenchymal stem cells (MSCs), as a kind of pluripotent stem cells, have attracted much
attention in orthopedic diseases, geriatric diseases, metabolic diseases, and sports …

The heterogeneity of the tumor microenvironment (TME) is a major obstacle in cancer
treatment, making most therapeutic interventions palliative rather than curative. Previous …

Osteoarthritis is a prevalent joint disease that significantly affects the daily life of the elderly
and is one of the primary causes of disability in this population. This study aims to evaluate …

Conventional chemotherapy represents the main systemic treatment used for triple-negative
breast cancer (TNBC) patients, although many of them develop drug resistance. The hypoxic …

Estrogen receptor-positive (ER+) breast cancer commonly disseminates to bone marrow,
where interactions with mesenchymal stromal cells (MSCs) shape disease trajectory. We …

The ability of cancer stem cells (CSCs) to self-renew, differentiate, and generate new tumors
is a significant contributor to drug resistance, relapse, and metastasis. Therefore, the …

Chemotherapy resistance in advanced gastric cancer (GC) patients has largely limited the
effectiveness of therapy, resulting in disease recurrence and poor prognosis. Gastric cancer …

Background Intrauterine adhesion (IUA) is a clinical disease characterized by the uterine
cavity occlusion caused by the damage of the endometrial basal layer. Bone marrow …

Simple Summary The pathogenesis of osteosarcoma relies on complex interactions
between developing cancer and surrounding tissue, which includes proteins of the …

An altered metabolism of iron fuels cancer growth, invasion, metastasis, and recurrence.
Ongoing research in cancer biology is delineating a complex iron-trafficking program …