An overview of microRNAs
SM Hammond - Advanced drug delivery reviews, 2015 - Elsevier
The discovery of the first microRNA (miRNA) over 20 years ago has ushered in a new era in
molecular biology. There are now over 2000 miRNAs that have been discovered in humans …
molecular biology. There are now over 2000 miRNAs that have been discovered in humans …
Adult stem cells at work: regenerating skeletal muscle
Skeletal muscle regeneration is a finely tuned process involving the activation of various
cellular and molecular processes. Satellite cells, the stem cells of skeletal muscle, are …
cellular and molecular processes. Satellite cells, the stem cells of skeletal muscle, are …
miRBase: from microRNA sequences to function
A Kozomara, M Birgaoanu… - Nucleic acids …, 2019 - academic.oup.com
Abstract miRBase catalogs, names and distributes microRNA gene sequences. The latest
release of miRBase (v22) contains microRNA sequences from 271 organisms: 38 589 …
release of miRBase (v22) contains microRNA sequences from 271 organisms: 38 589 …
Prediction of functional microRNA targets by integrative modeling of microRNA binding and target expression data
We perform a large-scale RNA sequencing study to experimentally identify genes that are
downregulated by 25 miRNAs. This RNA-seq dataset is combined with public miRNA target …
downregulated by 25 miRNAs. This RNA-seq dataset is combined with public miRNA target …
A circular RNA protects the heart from pathological hypertrophy and heart failure by targeting miR-223
K Wang, BO Long, F Liu, JX Wang, CY Liu… - European heart …, 2016 - academic.oup.com
Aims Sustained cardiac hypertrophy accompanied by maladaptive cardiac remodelling
represents an early event in the clinical course leading to heart failure. Maladaptive …
represents an early event in the clinical course leading to heart failure. Maladaptive …
Interplay between miRNAs and human diseases
P Paul, A Chakraborty, D Sarkar… - Journal of cellular …, 2018 - Wiley Online Library
MicroRNAs (miRNAs) are endogenous, non‐coding RNAs, which have evoked a great deal
of interest due to their importance in many aspects of homeostasis and diseases …
of interest due to their importance in many aspects of homeostasis and diseases …
Pkm2 regulates cardiomyocyte cell cycle and promotes cardiac regeneration
Background: The adult mammalian heart has limited regenerative capacity, mostly
attributable to postnatal cardiomyocyte cell cycle arrest. In the last 2 decades, numerous …
attributable to postnatal cardiomyocyte cell cycle arrest. In the last 2 decades, numerous …
[HTML][HTML] Muscle-specific microRNAs in skeletal muscle development
M Horak, J Novak, J Bienertova-Vasku - Developmental biology, 2016 - Elsevier
Proper muscle function constitutes a precondition for good heath and an active lifestyle
during an individual's lifespan and any deviations from normal skeletal muscle development …
during an individual's lifespan and any deviations from normal skeletal muscle development …
Mechanisms of miRNA‐mediated gene regulation from common downregulation to mRNA‐specific upregulation
A Valinezhad Orang, R Safaralizadeh… - … journal of genomics, 2014 - Wiley Online Library
Discovered in 1993, micoRNAs (miRNAs) are now recognized as one of the major
regulatory gene families in eukaryotes. To date, 24521 microRNAs have been discovered …
regulatory gene families in eukaryotes. To date, 24521 microRNAs have been discovered …
mRNA destabilization is the dominant effect of mammalian microRNAs by the time substantial repression ensues
MicroRNAs (miRNAs) regulate target mRNAs through a combination of translational
repression and mRNA destabilization, with mRNA destabilization dominating at steady state …
repression and mRNA destabilization, with mRNA destabilization dominating at steady state …