Emerging perspective: role of increased ROS and redox imbalance in skin carcinogenesis

D Xian, R Lai, J Song, X Xiong… - Oxidative medicine and …, 2019 - Wiley Online Library
Strategies to battle malignant tumors have always been a dynamic research endeavour.
Although various vehicles (eg, chemotherapeutic therapy, radiotherapy, surgical resection …

Oxidative stress and antioxidants in the pathophysiology of malignant melanoma

E Obrador, F Liu-Smith, RW Dellinger… - Biological …, 2019 - degruyter.com
The high number of somatic mutations in the melanoma genome associated with cumulative
ultra violet (UV) exposure has rendered it one of the most difficult of cancers to treat. With …

[HTML][HTML] Accelerating drug development for neuroblastoma: summary of the second neuroblastoma drug development strategy forum from innovative therapies for …

L Moreno, G Barone, SG DuBois, J Molenaar… - European Journal of …, 2020 - Elsevier
Only one class of targeted agents (anti-GD2 antibodies) has been incorporated into front-
line therapy for neuroblastoma since the 1980s. The Neuroblastoma New Drug …

Chemically-induced DNA damage, mutagenesis, and cancer

AK Basu, T Nohmi - International Journal of Molecular Sciences, 2018 - mdpi.com
A large fraction of human cancers arise from exposure to chemicals, although radiation,
oxidation, and genetic factors play critical roles as well. DNA damage by these agents in a …

Melanoma in the liver: Oxidative stress and the mechanisms of metastatic cell survival

E Obrador, R Salvador, R Lopez-Blanch… - Seminars in Cancer …, 2021 - Elsevier
Metastatic melanoma is a fatal disease with a rapid systemic dissemination. The most
frequent target sites are the liver, bone, and brain. Melanoma metastases represent a …

A possible link of genetic variations in ER/IGF1R pathway and risk of melanoma

TA Yuan, V Yourk, A Farhat, KL Guo, A Garcia… - International Journal of …, 2020 - mdpi.com
The mechanism of gender disparity in cutaneous melanoma incidence remains unclear.
Steroid hormones including estrogens have long been implicated in the course of …

[HTML][HTML] Studying the effects of haplotype partitioning methods on the RA-associated genomic results from the North American Rheumatoid Arthritis Consortium …

MN Saad, MS Mabrouk, AM Eldeib… - Journal of Advanced …, 2019 - Elsevier
The human genome, which includes thousands of genes, represents a big data challenge.
Rheumatoid arthritis (RA) is a complex autoimmune disease with a genetic basis. Many …

Immune expression signatures as candidate prognostic biomarkers of age and gender survival differences in cutaneous melanoma

YJ Kim, K Kim, KH Lee, J Kim, W Jung - Scientific Reports, 2020 - nature.com
This study aims to investigate the difference of gene expression and its prognostic
significance in younger women with melanoma. Significantly upregulated genes in tumors …

Transient and stable overexpression of extracellular superoxide dismutase is positively associated with the myogenic function of human skeletal muscle-derived stem …

M Nowaczyk, A Malcher, A Zimna, W Łabędź… - Antioxidants, 2020 - mdpi.com
In the present study, the genetic modification of human skeletal muscle-derived
stem/progenitor cells (SkMDS/PCs) was investigated to identify the optimal protocol for …

[HTML][HTML] Genetic variants in TKT and DERA in the nicotinamide adenine dinucleotide phosphate pathway predict melanoma survival

N Gu, W Dai, H Liu, J Ge, S Luo, E Cho, CI Amos… - European Journal of …, 2020 - Elsevier
Background Cutaneous melanoma (CM) is the most lethal type of skin cancers.
Nicotinamide adenine dinucleotide phosphate (NADPH) plays an important role in anabolic …