Biological differences among metazoans and between cell types in a given organism arise
in large part due to differences in gene expression patterns. Gene-distal enhancers are key …

The control of gene expression involves regulatory elements that can be very far from the
genes they control. Several recent technological advances have allowed the direct detection …

Chromatin looping is key to gene regulation, yet no broadly applicable methods to
selectively modify chromatin loops have been described. We have engineered a method for …

Chromatin loops juxtapose distal enhancers with active promoters, but their molecular
architecture and relationship with transcription remain unclear. In erythroid cells, the locus …

Interphase chromatin is organized into topologically associating domains (TADs). Within
TADs, chromatin looping interactions are formed between DNA regulatory elements, but …

While GWAS identify many disease-associated SNPs, using them to decipher disease
mechanisms is hindered by the difficulty in mapping SNPs to genes. Most SNPs are in non …

Abstract Three-dimensional (3D) genome folding has a fundamental role in the regulation of
developmental genes by facilitating or constraining chromatin interactions between cis …

Following fertilization, the genomes of the germ cells are reprogrammed to form the
totipotent embryo. Pioneer transcription factors are essential for remodeling the chromatin …

Chromatin accessibility, a crucial component of genome regulation, has primarily been
studied in homogeneous and simple systems, such as isolated cell populations or early …

Studies on genetic–epigenetic interactions, including the mapping of methylation
quantitative trait loci (mQTLs) and haplotype-dependent allele-specific DNA methylation …