Nowadays, obesity is one of the largest public health problems worldwide. In the last few
decades, there has been a marked increase in the obesity epidemic and its related …

Valproic acid (VPA) and its salts are psychotropic drugs that are widely used in neurological
diseases (epilepsy, neuropathic pain, migraine, etc.) and psychiatric disorders …

Spinal muscular atrophy (SMA) is a motor-neuron disease caused by mutations of the SMN1
gene. The human paralog SMN2, whose exon 7 (E7) is predominantly skipped, cannot …

Disruption of the epigenetic program of gene expression is a hallmark of cancer that initiates
and propagates tumorigenesis. Altered DNA methylation, histone modifications and ncRNAs …

The kynurenine pathway (KP) is abnormal in autistic patients and model animals. According
to studies on the brain–gut axis, probiotics can help ameliorate the metabolic abnormalities …

Epilepsy is a common neurological disorder characterized by recurrent seizures with
excessive and abnormal neuronal discharges. Epileptogenesis is usually involved in …

Background Valproic acid (VPA) is a widely used antiepileptic drug (AED) often prescribed
as a first-line treatment for many idiopathic and symptomatic generalized epilepsies. Several …

Neuroplasticity is a crucial property of the central nervous system to change its activity in
response to intrinsic or extrinsic stimuli. This is mainly achieved through the promotion of …

Abstract Cordycepin (3′-deoxyadenosine) is a nucleoside analogue and biosynthesised by
Cordyceps militaris, an entomopathogenic fungus. In this study, an epigenetic modifier was …

Sulforaphane has been investigated in human pathologies and preclinical models of airway
diseases. To provide further mechanistic insights, we explored L-sulforaphane (LSF) in the …