Animal behavior is shaped by a variety of" internal states"—partially hidden variables that
profoundly shape perception, cognition, and action. The neural basis of internal states, such …

Chemosensory neurons translate perception of external chemical cues, including odorants,
tastants, and pheromones, into information that drives attraction or avoidance motor …

Animals coexist in commensal, pathogenic or mutualistic relationships with complex
communities of diverse organisms, including microorganisms. Some bacteria produce …

Animals generate complex patterns of behavior across development that may be shared or
unique to individuals. Here, we examine the contributions of developmental programs and …

There is growing interest in pharmacological interventions directly targeting the aging
process. Pharmacological interventions against aging should be efficacious when started in …

Key discoveries in aging research have been made possible with the use of model
organisms. Caenorhabditis elegans is a short-lived nematode that has become a well …

Animal internal state is modulated by nutrient intake, resulting in behavioral responses to
changing food conditions. The neural mechanisms by which internal states are generated …

In a typical high-throughput drug screening (HTS) process, up to millions of chemical
compounds are applied to cells cultured in well plates, aiming to find molecules that exhibit …

An organism's ability to perceive and respond to changes in its environment is crucial for its
health and survival. Here we reveal how the most well-studied longevity intervention, dietary …

Health and longevity in all organisms are strongly influenced by the environment. To fully
understand how environmental factors interact with genetic and stochastic factors to …