Mitochondria are key structures providing most of the energy needed to maintain
homeostasis. They are the main source of adenosine triphosphate (ATP), participate in …

Calcium research, since its pivotal discovery in the early 1800s through the heating of
limestone, has led to the identification of its multi-functional roles. These include its functions …

Glucocorticoid steroids are commonly prescribed for many inflammatory conditions, but
chronic daily use produces adverse effects, including muscle wasting and weakness. In …

Molecular targets to reduce muscle weakness and atrophy due to oxidative stress have
been elusive. Here we show that activation of Sarcoplasmic Reticulum (SR) Ca 2+ ATPase …

Sarcopenia has a significant negative impact on healthspan in the elderly and effective
pharmacologic interventions remain elusive. We have previously demonstrated that …

Good health depends on the maintenance of metabolic flexibility, which in turn is dependent
on the maintenance of regulatory flexibility of a large number of regulatory enzymes, but …

Polyglutamine expansion in the androgen receptor (AR) causes spinobulbar muscular
atrophy (SBMA). Skeletal muscle is a primary site of toxicity; however, the current …

Drinking tea has been proven to have a positive biological effect in regulating human
glucose and lipid metabolism and preventing type 2 diabetes (T2D). Skeletal muscle (SkM) …

The physical contact site between a mitochondrion and endoplasmic reticulum (ER), named
the mitochondria-associated membrane (MAM), has emerged as a fundamental platform for …

Despite vitamin D‐deficiency clinically presenting with myopathy, muscle weakness and
atrophy, the mechanisms by which vitamin D exerts its homeostatic effects upon skeletal …