Numerous mitochondrial constituents and metabolic products can function as damage-
associated molecular patterns (DAMPs) and promote inflammation when released into the …

According to the endosymbiotic theory, most of the DNA of the original bacterial
endosymbiont has been lost or transferred to the nucleus, leaving a much smaller (∼ 16 kb …

Low back pain (LBP) is a major musculoskeletal disorder and the socioeconomic problem
with a high prevalence that mainly involves intervertebral disc (IVD) degeneration …

Mitochondrial DNA (mtDNA) encodes essential subunits of the oxidative phosphorylation
system, but is also a major damage-associated molecular pattern (DAMP) that engages …

Mitochondria retain bacterial traits due to their endosymbiotic origin, but host cells do not
recognize them as foreign because the organelles are sequestered. However, the regulated …

Abstract Influenza A Virus (IAV) is a recurring respiratory virus with limited availability of
antiviral therapies. Understanding host proteins essential for IAV infection can identify …

Fever is a common symptom of influenza and coronavirus disease 2019 (COVID-19), yet its
physiological role in host resistance to viral infection remains less clear. Here, we …

The past decade has provided critical information about the cytoplasmic innate immune
sensing pathway of cyclic GMP-AMP synthase (cGAS) and stimulator of interferon genes …

Activation of the cGAS-STING pathway is traditionally considered a “trigger-release”
mechanism where detection of microbial DNA or cyclic di-nucleotides sets off the type I …

Host: pathogen interactions dictate the outcome of infection, yet the limitations of current
approaches leave large regions of this interface unexplored. Here, we develop a novel …