MicroRNAs as therapeutic targets in cardiovascular disease

B Laggerbauer, S Engelhardt - The Journal of clinical …, 2022 - Am Soc Clin Investig
The discovery of microRNAs and their role in diseases was a breakthrough that inspired
research into microRNAs as drug targets. Cardiovascular diseases are an area in which …

MicroRNAs: roles in cardiovascular development and disease

S Kalayinia, F Arjmand, M Maleki, M Malakootian… - Cardiovascular …, 2021 - Elsevier
Cardiovascular diseases (CVDs) comprise a group of disorders ranging from peripheral
artery, coronary artery, cardiac valve, cardiac muscle, and congenital heart diseases to …

A novel circulating noncoding small RNA for the detection of acute myocarditis

R Blanco-Domínguez, R Sánchez-Díaz… - … England Journal of …, 2021 - Mass Medical Soc
Background The diagnosis of acute myocarditis typically requires either endomyocardial
biopsy (which is invasive) or cardiovascular magnetic resonance imaging (which is not …

Precision medicine and the future of cardiovascular diseases: a clinically oriented comprehensive review

Y Sethi, N Patel, N Kaka, O Kaiwan, J Kar… - Journal of clinical …, 2023 - mdpi.com
Cardiac diseases form the lion's share of the global disease burden, owing to the paradigm
shift to non-infectious diseases from infectious ones. The prevalence of CVDs has nearly …

miR-21: a non‐specific biomarker of all maladies

AE Jenike, MK Halushka - Biomarker research, 2021 - Springer
Abstract miRNA-21 is among the most abundant and highly conserved microRNAs
(miRNAs) recognized. It is expressed in essentially all cells where it performs vital regulatory …

Crafting a blueprint for MicroRNA in cardiovascular diseases (CVDs)

SU Khan, S Saeed, AN Sheikh, FM Arbi… - Current Problems in …, 2023 - Elsevier
Cardiovascular diseases (CVDs) encompass a range of disorders, from congenital heart
malformation, cardiac valve, peripheral artery, coronary artery, cardiac muscle diseases, and …

[HTML][HTML] Tight junctions and their regulation by non-coding RNAs

X Zhao, H Zeng, L Lei, X Tong, L Yang… - … Journal of Biological …, 2021 - ncbi.nlm.nih.gov
Tight junction (TJ) is a “zippering up” junction structure located at the uppermost portion of
adjacent epithelial/endothelial cells in organs and tissues. TJs maintain the relative stability …

miR‐1, miR‐499 and miR‐208 are sensitive markers to diagnose sudden death due to early acute myocardial infarction

E Pinchi, P Frati, M Aromatario… - Journal of cellular …, 2019 - Wiley Online Library
MicroRNAs (miRNAs) are strongly up‐regulated under pathological stress and in a wide
range of diseases. In recent years, miRNAs are under investigation for their potential use as …

[HTML][HTML] Exosomal RNAs in diagnosis and therapies

P Narang, M Shah, V Beljanski - Non-coding RNA Research, 2022 - Elsevier
The field of extracellular vesicles has been rapidly developing after it became evident that a
defined subset of vesicles, called exosomes, can modulate several biological functions in …

Small things matter: relevance of microRNAs in cardiovascular disease

LJF Peters, EAL Biessen, M Hohl, C Weber… - Frontiers in …, 2020 - frontiersin.org
MicroRNAs (miRNAs) are short sequences of non-coding RNA that play an important role in
the regulation of gene expression and thereby in many physiological and pathological …