Integrins are heterodimeric cell surface receptors ensuring the mechanical connection
between cells and the extracellular matrix. In addition to the anchorage of cells to the …

The integrins are a large family of cell adhesion molecules that are essential for the
regulation of cell growth and function. The identification of key roles for integrins in a diverse …

The role of platelets in hemostasis and thrombosis is dependent on a complex balance of
activatory and inhibitory signaling pathways. Inhibitory signals released from the healthy …

The ability of cells to attach to each other and to the extracellular matrix is of pivotal
significance for the formation of functional organs and for the distribution of cells in the body …

Integrins are heterodimeric cell surface adhesion receptors essential for multicellular life.
They connect cells to the extracellular environment and transduce chemical and mechanical …

Mitogen-activated protein kinases (MAPK), p38, and extracellular stimuli-responsive kinase
(ERK), are acutely but transiently activated in platelets by platelet agonists, and the agonist …

Platelets are small anucleated cells that constantly patrol the cardiovascular system to
preserve its integrity and prevent excessive blood loss where the vessel lining is breached …

Platelet activation must be tightly controlled in order to allow platelets to respond rapidly to
vascular injury and prevent thrombosis from occurring. Protein‐tyrosine phosphorylation is …

Integrins are heterodimeric transmembrane adhesion receptors composed of α-and β-
subunits. They are ubiquitously expressed and have key roles in a number of important …

MASTL, a Ser/Thr kinase that inhibits PP2A-B55 complexes during mitosis, is mutated in
autosomal dominant thrombocytopenia. However, the connections between the cell-cycle …