Human carbonic anhydrase (CA) IX is a tumor‐associated protein, since it is scarcely
present in normal tissues, but highly overexpressed in a large number of solid tumors, where …

Monoclonal antibody-based treatment of cancer has been established as one of the most
successful therapeutic strategies for both hematologic malignancies and solid tumors in the …

Introduction• Intracellular pH regulation controls energy balance and cell proliferation:
chemical and biological proof of principle‐Chemical proof of principle‐Biological proof of …

User-friendly and concise, the new edition of this popular reference is your# 1 guide for the
appropriate use of immunohistochemical stains. Dr. David J. Dabbs and leading experts in …

Conventional external-beam radiation therapy is dedicated to the treatment of localized
disease, whereas radioimmunotherapy represents an innovative tool for the treatment of …

Over 50 genes are inducible by hypoxia, via hypoxia inducible factor 1a (HIF-1a). Carbonic
anhydrase IX (CAIX) is one of the most inducible and most uniformly induced genes and …

Dysregulation of cellular pH is frequent in solid tumours and provides potential opportunities
for therapeutic intervention. The acidic microenvironment within a tumour can promote …

Targeted delivery of chemotherapeutics aims to increase efficacy and lower toxicity by
concentrating drugs at the site-of-action, a method embodied by the seven current FDA …

Cancer accounts for 13% of the yearly total mortality worldwide. Most cancer deaths are the
sequel of metastatic diseases rather than of primary tumor growth. Thus, the major challenge …

The concept of radioguided surgery, which was first developed some 60 years ago, involves
the use of a radiation detection probe system for the intraoperative detection of …