In the hippocampus GABAergic local circuit inhibitory interneurons represent only~ 10–15%
of the total neuronal population; however, their remarkable anatomical and physiological …

Until recently, the study of plasticity of neural circuits focused almost exclusively on
potentiation and depression at excitatory synapses on principal cells. Other elements in the …

Prediabetes and Alzheimer's disease both increase in prevalence with age. The former is a
risk factor for the latter, but a mechanistic linkage between them remains elusive. We show …

Rapid memory formation relies, at least in part, on long-term potentiation (LTP) of excitatory
synapses. Inhibitory interneurons of the hippocampus, which are essential for information …

Calcium/calmodulin-dependent protein kinase II (CaMK II) is found throughout the CNS. It
regulates calcium signaling in synaptic transmission by phosphorylating various proteins …

Cortical information processing requires a delicate balance of excitatory and inhibitory
signaling. How is this balance preserved during hippocampal memory encoding, which …

Mental experiences can become long-term memories if the hippocampal activity patterns
that encode them are broadcast during network oscillations. The activity of inhibitory …

Neuronal migration and positioning in the developing brain require the coordinated
interaction of multiple cellular signaling pathways. The extracellular signaling molecule …

Neurogliaform cells in the rat elicit combined GABAA and GABAB receptor-mediated
postsynaptic responses on cortical pyramidal cells and establish electrical synapses with …

Recent studies of excitatory transmission in cortical interneurons reveal a surprising diversity
of forms of long-term plasticity. LTP and LTD can be elicited at many synapses on …